白芨超微粉对大鼠实验性胃溃疡的影响

目的 通过大鼠胃溃疡实验比较白芨普通粉(80、200目)和超微粉的药效学区别及白芨经超微粉碎后可降低的用药剂量.方法 采用大鼠无水乙醇和醋酸致胃黏膜损伤型胃溃疡模型,测定溃疡面积,计算溃疡抑制率;取溃疡部组织切片,做HE染色,从病理学角度进一步观察病理情况.结果 白芨粉可明显降低大鼠的溃疡面积,且超微粉疗效优于普通粉.结论 超微粉碎后有助于提高白芨的药效,减少用药剂量,有利于剂型现代化.

Effect of ultra-fine powder of Bletillas triata on experimental gastriculcerin rats

ObjectiveTo compare the pharmacodynamics of common Bletilla striata powder (80 and 200 meshes) with ultrafine powder of B.striataon experimental gastriculcer in rats and to clarify how much the dose of B. striata was decreased after superfine comminution. Methods The models of gastriculcer were set up by anhydrous alcohol and aceticacid to measure the gastriculcer area and countout the inhibitory rate; The tissue slice of gastriculcer cicatrix was got far HE staining. Based on the viewpoint of pathology the morbid state was observed. ResultsB. striata powder could decrease the gastriculcer area significantly, and the groups of ultrafine powder were advantaged to the others. ConclusionA fter superfine comminution, the potency of B. striata can be improved with its dose reducing. It is good for modernization of making dosage forms.