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HPLC法研究泻心汤中大黄和黄芩配伍的活性成分变化
引用本文:何毓敏,张艺,孟宪丽,王平,王毓杰,熊玉霞.HPLC法研究泻心汤中大黄和黄芩配伍的活性成分变化[J].中草药,2007,38(5):699-702.
作者姓名:何毓敏  张艺  孟宪丽  王平  王毓杰  熊玉霞
作者单位:1. 成都中医药大学民族医药研究所,四川,成都,611730
2. 成都中医药大学,药理研究室,四川,成都,611730
摘    要:目的研究泻心汤中大黄和黄芩配伍前后的活性成分变化。方法采用HPLC法对两药合煎液和单煎混合液的各峰进行检测和分析,并对两药合煎液和单煎混合液中黄芩苷、大黄素等活性成分进行测定和动态分析。结果大黄与黄芩配伍合煎后产生了活性成分的动态变化。结论中药复方配伍并非是单味药的简单加合,本实验结果有助于阐明泻心汤的化学成分基础。

关 键 词:泻心汤  大黄  黄芩  配伍
文章编号:0253-2670(2007)05-0699-04
收稿时间:2006/8/16 0:00:00
修稿时间:2006-08-16

Effective component changes in compatibility of Radix et Rhizoma Rhei with Radix Scutellariae in Xiexin Decoction
HE Yu-min,ZHANG Yi,MENG Xian-li,WANG Ping,WANG Yu-jie and XIONG Yu-xia.Effective component changes in compatibility of Radix et Rhizoma Rhei with Radix Scutellariae in Xiexin Decoction[J].Chinese Traditional and Herbal Drugs,2007,38(5):699-702.
Authors:HE Yu-min  ZHANG Yi  MENG Xian-li  WANG Ping  WANG Yu-jie and XIONG Yu-xia
Institution:1. Institute of Ethnomedieine, Chengdu University of Traditional Chinese Medicine, Chengdu 611730, China; 2. Research Laboratory of Pharmacology, Chengdu University of Traditional Chinese Medicine, Chengdu 611730, China
Abstract:Objective To explore the chemical components changes in compatibility of Radix et Rhizoma Rhei with Radix Scutellariae in Xiexin Decoction. Methods HPLC Chromatograms were used to study the peak changes of single and co-decoction of Radixet Rhizoma Rhei with Radix Scutellariae, as well as the effective components were determined and analysed. Results The significant changes of baicaclin, rhein, emodin, chrysophanol, and physcion had been found. Conclusion Compatibility of Chinese herbal medicines doesnt mean adding single herb simply and this test is just an attempt to elucidate the chemical foundation of Xiexin Decoction.
Keywords:Xiexin Decoction  Radix et Rhizoma Rhei  Radix Scutellariae  compatibility
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