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新型伤湿止痛贴膏剂体外释药规律研究
引用本文:黎丽,闫小平,郑蕊,毛超一.新型伤湿止痛贴膏剂体外释药规律研究[J].中草药,2011,42(12):2430-2433.
作者姓名:黎丽  闫小平  郑蕊  毛超一
作者单位:1. 中国中医科学院西苑医院,北京,100091
2. 中国中医科学院,北京,100700
基金项目:“十一五”中医外治特色疗法和外治技术示范研究(2008BAI53B076)
摘    要:目的 研究新型伤湿止痛贴膏剂(热熔压敏胶基质)体外透皮速率和释放规律.方法 采用 HPLC 法测定透皮接收液和释放液中指标成分马钱子碱、士的宁和硫酸阿托品的量,计算其体外透皮速率和释放速率.结果 马钱子碱、士的宁和硫酸阿托品在体外透皮试验中,分别以7.44%·h-1/2、10.53%·h-1/2、4.73%·h-1/2的速率恒速渗透;体外释药速率分别为10.35%·h-1/2、18.1 3%·h-1/2、4.88%·h-1/2,其释放过程符合Higuchi方程.结论 以热熔压敏胶为基质的新型伤湿止痛贴膏剂为骨架控释型释药系统.

关 键 词:伤湿止痛贴膏  马钱子碱  士的宁  硫酸阿托品  体外透皮渗透  体外释放
收稿时间:2011/5/10 0:00:00

Determination of in vitro release rule of new type Shangshi Zhitong Plaster
LI Li,YAN Xiao-ping,ZHENG Rui and MAO Chao-yi.Determination of in vitro release rule of new type Shangshi Zhitong Plaster[J].Chinese Traditional and Herbal Drugs,2011,42(12):2430-2433.
Authors:LI Li  YAN Xiao-ping  ZHENG Rui and MAO Chao-yi
Institution:LI Li1,YAN Xiao-ping1,ZHENG Rui1,MAO Chao-yi2 1.Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China 2.China Academy of Chinese Medical Sciences,Beijing 100700,China
Abstract:Objective To determine the percutaneous rate and in vitro drug release rule of new type Shangshi Zhitong Plaster(hot-melt pressure sensitive adhesive).Methods The content of brucine,strychnine,and Atropine sulphate in percutaneous reception fluid and release fluid were determined by HPLC,and the in vitro percutaneous rate and in vitro drug release rate were computed.Results The in vitro percutaneous permeation at a constant rate of brucine,strychnine,and atropine were 7.44%.h?1/2,10.53%.h?1/2,and 4.73%.h?1/...
Keywords:Shangshi Zhitong Plaster  strychnine  brucine  Atropine sulphate  in vitro percutaneous permeation  in vitro release  
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