| 基于薄荷油为油相的红花提取物自微乳凝胶递送系统制备研究 |
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| 引用本文： | 贺智勇,邹弢,罗田,李婉蓉,杨佳佳,刘学,肖婷,周雪,吴林菁,刘文,沈祥春,陶玲.基于薄荷油为油相的红花提取物自微乳凝胶递送系统制备研究[J].中草药,2020,51(11):2922-2928. |
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| 作者姓名： | 贺智勇 邹弢 罗田 李婉蓉 杨佳佳 刘学 肖婷 周雪 吴林菁 刘文 沈祥春 陶玲 |
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| 作者单位： | 贵州医科大学药学院 贵州省天然药物资源高效利用工程中心, 贵州省高等学校天然药物药理与成药性评价特色重点实验室, 贵州医科大学-贵阳市联合重点实验室, 天然药物资源优效利用重点实验室, 贵州 贵阳 550025;宮崎大学医学部 機能制御学講座 物質科学分野 日本宮崎県宮崎市清武町木原5200番地 889-1692, 日本;贵州医科大学药学院 贵州省天然药物资源高效利用工程中心, 贵州省高等学校天然药物药理与成药性评价特色重点实验室, 贵州医科大学-贵阳市联合重点实验室, 天然药物资源优效利用重点实验室, 贵州 贵阳 550025;贵州省骨科医院, 贵州 贵阳 550002;贵州医科大学药学院 贵州省天然药物资源高效利用工程中心, 贵州省高等学校天然药物药理与成药性评价特色重点实验室, 贵州医科大学-贵阳市联合重点实验室, 天然药物资源优效利用重点实验室, 贵州 贵阳 550025;贵州医科大学附属医院, 贵州 贵阳 550004 |
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| 基金项目： | 贵州省天然药物成药性人才基地[黔人颁发（2018）3号]；贵州省高层次创新型人才"百层次"人才项目[黔科合人才（2015）4029号]；贵州省科技厅国际合作项目[黔科合外G字（2012）7041号] |
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| 摘 要： | 目的制备以薄荷油(Menthaha plocalyx oil,MPO)为油相的红花提取物(Carthamus tinctorius extract,CTE)自微乳凝胶递送系统(CTE-SMEDDS-BGs)。方法以MPO为油相,CTE为水相,采用伪三元相图法优选载药自微乳处方,采用单因素法筛选凝胶工艺与处方,并对其外观性状、黏度和pH值进行评价。结果所得CTE-SMEDDS-BGs最佳处方工艺:F68为乳化剂,无水乙醇为助乳化剂,乳化剂与助乳化剂比例(Km)为1∶1,乳化剂和助乳化剂总量(TS)与MPO的比例为8∶2,卡波姆2%,甘油6%,CTE5m L。处方量自微乳加入溶胀后的凝胶基质,三乙胺调节pH值至6.0即得CTE-SMEDDS-BGs;其外观为黄色半透明、黏稠度适中、均匀细腻、不油腻,易涂展的胶状凝胶,黏度为4.98×10~4m Pa·s(RSD为1.53%),pH为6.04(RSD为0.44%)。结论制得的薄荷油为油相的CTE-SMEDDS-BGs,制备简便,方法稳定,符合凝胶局部外用制剂要求。
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| 关 键 词： | 红花提取物 薄荷油 自微乳 凝胶 递送系统 伪三元相图法 局部外用 |
| 收稿时间： | 2020/1/3 0:00:00 |
Preparation of self-microemulsion gel drug delivery system of Carthamus tinctorius extract based on Mentha haplocalyx oil as oil phase |
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| HE Zhi-yong,ZOU Tao,LUO Tian,LI Wan-rong,YANG Jia-ji,LIU Xue,XIAO Ting,ZHOU Xue,WU Lin-jing,LIU Wen,SHEN Xiang-chun,TAO Ling.Preparation of self-microemulsion gel drug delivery system of Carthamus tinctorius extract based on Mentha haplocalyx oil as oil phase[J].Chinese Traditional and Herbal Drugs,2020,51(11):2922-2928. |
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| Authors: | HE Zhi-yong ZOU Tao LUO Tian LI Wan-rong YANG Jia-ji LIU Xue XIAO Ting ZHOU Xue WU Lin-jing LIU Wen SHEN Xiang-chun TAO Ling |
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| Institution: | Key Laboratory of Functions and Applications of Medicinal Plants, High Educational Key Laboratory of Natural Medicinal Pharmacology and Druggability of Guizhou Province, Guizhou Medical University-Guiyang Key Laboratory of Natural Medicine Resources, Key Laboratory of Optimal Utilization of Natural Medicinal Resources, School of Pharmacy, Guizhou Medical University, Guiyang 550025, China;Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan;Key Laboratory of Functions and Applications of Medicinal Plants, High Educational Key Laboratory of Natural Medicinal Pharmacology and Druggability of Guizhou Province, Guizhou Medical University-Guiyang Key Laboratory of Natural Medicine Resources, Key Laboratory of Optimal Utilization of Natural Medicinal Resources, School of Pharmacy, Guizhou Medical University, Guiyang 550025, China;Guizhou Orthopedics Hospital, Guiyang 550002, China;Key Laboratory of Functions and Applications of Medicinal Plants, High Educational Key Laboratory of Natural Medicinal Pharmacology and Druggability of Guizhou Province, Guizhou Medical University-Guiyang Key Laboratory of Natural Medicine Resources, Key Laboratory of Optimal Utilization of Natural Medicinal Resources, School of Pharmacy, Guizhou Medical University, Guiyang 550025, China;Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China |
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| Abstract: | |
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| Keywords: | Carthamus tinctorius extract Mentha haplocalyx oil self-microemulsion gel delivery system pseudo-ternary phase diagram topical application |
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