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栀子的抗炎镇痛作用研究
引用本文:朱江,蔡德海,芮菁.栀子的抗炎镇痛作用研究[J].中草药,2000,31(3):198-200.
作者姓名:朱江  蔡德海  芮菁
作者单位:1. 武警医学院药理教研室,天津,300162
2. 天津市药品检验所
摘    要:用3.0和1.0g浸膏/kg2个剂量进行试验,探讨单味桅子75%甲醇提取物对炎症组织的影响,结果表明,桅子浸膏可显著抑制醋酸诱发血管通透性增加,高、低剂量的抑制率分别为44.7%和25.6%;显著抑制叉菜所致大鼠足肿胀作用,第6小时抑制率分别为33.6%和25.4%;显著抑制棉球肉芽组织增生,抑制率分别为54.1%和33.0%;对醋酸诱发的小鼠扭体反应有一定抑制作用,抑制率分别为26.8%和18.

关 键 词:桅子  抗炎  镇痛  中药
收稿时间:1999/9/20 0:00:00
修稿时间:1999-09-20

Antiinflammatory and Analgesic Effects of Cape Jasmine (Gardenia jasminoides)
Zhu Jiang,Cai Dehai Tianjin and Rui Jing.Antiinflammatory and Analgesic Effects of Cape Jasmine (Gardenia jasminoides)[J].Chinese Traditional and Herbal Drugs,2000,31(3):198-200.
Authors:Zhu Jiang  Cai Dehai Tianjin and Rui Jing
Institution:Tianjin 300162
Abstract:The antiinflammatory and analgesic effects of a 75% methanolic extract of Gardenia jasminoides Ellis were studied at a high dose (3 0 g/kg) and a low dose (1 0 g/kg) in experimental animals. Results showed that the extract significantly inhibited the increase of dye exudation induced by acetic acid of 44 7% and 25 6%; significantly inhibited carrageenin induced rat paw edema of 33.6% and 25.4% at 6 h; significantly inhibited cotton pellet induced granuloma formation of 54.1% and 33.0%; reduced the number of writhes induced by acetic acid of 26.8% and 18.9% at high and low doses respectively. These results indicated that the 75% methanolic extract obtained from G. Jasminoides have significant antiinflammatory and analgesic effects.
Keywords:Gardenia jasminoides Ellis  antiinflammatory effect  inflammatory exudation  paw edema  proliferation of granuloma  writhing symptom
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