| 基于超高效液相色谱-四级杆飞行时间串联质谱和网络药理学的甘枣宁治疗非酒精性脂肪性肝病药效物质基础研究 |
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| 引用本文： | 王婉先,姚曼,余钦,李一璇,凌昌全. 基于超高效液相色谱-四级杆飞行时间串联质谱和网络药理学的甘枣宁治疗非酒精性脂肪性肝病药效物质基础研究[J]. 中草药, 2021, 52(12): 3591-3601 |
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| 作者姓名： | 王婉先 姚曼 余钦 李一璇 凌昌全 |
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| 作者单位： | 上海中医药大学, 上海 201203;海军军医大学中医系, 上海 200433;海军军医大学附属长海医院中医肿瘤科, 上海 200433;上海中医药大学附属岳阳医院, 上海 200437 |
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| 摘 要： | 目的 探究甘枣宁的主要活性成分,预测并验证其治疗非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的主要物质基础.方法 采用超高效液相色谱-四级杆飞行时间串联质谱(UPLC-Q-TOF-MS/MS),明确甘枣宁水煎液的化学成分.采用网络药理学方法检索甘枣宁活性成分及其潜...
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| 关 键 词： | 甘枣宁 非酒精性脂肪性肝病 超高效液相色谱-四级杆飞行时间串联质谱 网络药理学 N-去甲基荷叶碱 |
| 收稿时间： | 2020-12-16 |
Pharmacodynamic material basis of Ganzaoning for treatment of non-alcoholic fatty liver disease based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and network pharmacology |
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| WANG Wan-xian,YAO Man,YU Qin,LI Yi-xuan,LING Chang-quan. Pharmacodynamic material basis of Ganzaoning for treatment of non-alcoholic fatty liver disease based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and network pharmacology[J]. Chinese Traditional and Herbal Drugs, 2021, 52(12): 3591-3601 |
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| Authors: | WANG Wan-xian YAO Man YU Qin LI Yi-xuan LING Chang-quan |
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| Affiliation: | Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Department of Traditional Chinese Medicine, the Second Military Medical University, Shanghai 200433, China;Department of Traditional Chinese Medicine Oncology, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433, China;Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China |
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| Abstract: | |
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| Keywords: | Ganzaoning non-alcoholic fatty liver ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry network pharmacology N-nornuciferine |
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