| 地黄苷A对环磷酰胺致小鼠白细胞减少症的影响 |
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| 引用本文： | 于震,王军,李更生,王玉升.地黄苷A对环磷酰胺致小鼠白细胞减少症的影响[J].中草药,2001,32(11):1002-1004. |
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| 作者姓名： | 于震 王军 李更生 王玉升 |
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| 作者单位： | 河南省中医药研究院, |
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| 基金项目： | 国家中医药管理局资助(No.95Y3411);国家"九·五"科技攻关项目(No.96-903-02-04) |
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| 摘 要： | 日的 观察地黄苷A对环磷酰胺致小鼠白细胞减少症的影响。方法 利用环磷酰胺ip造成小鼠白细胞减少症模型，地黄苷A进行治疗，对模型小鼠体重、外周血象、网织红细胞数、脾脏指数、骨髓有核细胞数和DNA含量进行检测。结果 地黄苷A可明显升高模型小鼠的白细胞数、红细胞数、血小板数，网织红细胞数、骨髓有核细胞数和DNA含量及体重，结论 地黄苷A具有明显升白作用。
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| 关 键 词： | 地黄苷A 环磷酰胺 白细胞减少症 升白作用 小鼠 中医药治疗 |
| 文章编号： | 0253-2670(2001)11-1002-00 |
| 收稿时间： | 2001/2/19 0:00:00 |
| 修稿时间： | 2001年2月19日 |
Effect of rehmaionoside A on cyclophosphamide induced leukopenia in mice |
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| YU Zhen,WANG Jun,LI Gengsheng and WANG Yusheng.Effect of rehmaionoside A on cyclophosphamide induced leukopenia in mice[J].Chinese Traditional and Herbal Drugs,2001,32(11):1002-1004. |
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| Authors: | YU Zhen WANG Jun LI Gengsheng and WANG Yusheng |
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| Institution: | Henan Academy of TCM, Zhengzhou Henan 450004, China;Henan Academy of TCM, Zhengzhou Henan 450004, China;Henan Academy of TCM, Zhengzhou Henan 450004, China;Henan Academy of TCM, Zhengzhou Henan 450004, China |
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| Abstract: | Object To observe the effects of rehmaionoside A on mice leukopenia models induced by cyclophosphamide. Methods Mice leukopenia models were prepared by ip cyclophosphamide and then treated with rehmaionoside A. The levels of body weight, peripheral hemogram, reticulocyte count, spleen index, bone marrow karyocyte count and contents of bone marrow DNA were determined. Results Rehmaionoside A could obviously raise the counts of white blood cell, red blood cell, platelet, reticulocyte and bone marrow karyocyte, contents of bone marrow DNA, and body weight of the leukopenia model. Conclusion Rehmaionoside A has apparent leukogenic and antianemic actions. |
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| Keywords: | rehmaionoside A cyclophosphamide leukopenia leukogenic action |
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