| 配伍对葛根芩连汤中甘草酸含量的影响 |
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| 引用本文： | 戴开金,罗佳波,吴昭晖,谭晓梅,任建生.配伍对葛根芩连汤中甘草酸含量的影响[J].中草药,2003,34(12):1084-1087. |
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| 作者姓名： | 戴开金 罗佳波 吴昭晖 谭晓梅 任建生 |
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| 作者单位： | 第一军医大学,中药制剂研究重点实验室,广东,广州,510515 |
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| 基金项目： | 国家自然科学基金面上重点资助项目(3 9970 886)，广东省自然科学基金资助项目 (0 0 10 70 ) |
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| 摘 要： | 目的 研究配伍对葛根芩连汤中甘草酸含量的影响。方法 采用 L8( 2 7)正交设计及统计软件 SPSS 10 .0统计处理 ,以 HPL C法测定配伍中甘草酸含量。结果 黄连对甘草酸的含量影响差异具有显著性 ( P<0 .0 5 ) ,黄芩、葛根对甘草酸含量影响差异无显著性 ,三者两两交互作用不显著 ,黄连和甘草配伍煎液中产生沉淀 ,且其含有一定量的甘草酸。结论 黄连降低葛根芩连汤中甘草酸的含量 ,黄芩、葛根对其含量没有影响
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| 关 键 词： | 葛根芩连汤 配伍 甘草酸 高效液相色谱 |
| 文章编号： | 0253-2670(2003)12-1084-04 |
| 收稿时间： | 2003/3/10 0:00:00 |
| 修稿时间： | 2003年3月10日 |
Influence of compatibility on glycyrrhizinic acid in Gegen Qinlian Decoction |
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| DAI Kai jin,LUO Jia bo,WU Zhao hui,TAN Xiao mei and REN Jian sheng.Influence of compatibility on glycyrrhizinic acid in Gegen Qinlian Decoction[J].Chinese Traditional and Herbal Drugs,2003,34(12):1084-1087. |
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| Authors: | DAI Kai jin LUO Jia bo WU Zhao hui TAN Xiao mei and REN Jian sheng |
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| Institution: | Key Laboratory of Pharmaceutics of Chinese Materia Medica, First Military Medical University, Guangzhou 510515, China;Key Laboratory of Pharmaceutics of Chinese Materia Medica, First Military Medical University, Guangzhou 510515, China;Key Laboratory of Pharmaceutics of Chinese Materia Medica, First Military Medical University, Guangzhou 510515, China;Key Laboratory of Pharmaceutics of Chinese Materia Medica, First Military Medical University, Guangzhou 510515, China;Key Laboratory of Pharmaceutics of Chinese Materia Medica, First Military Medical University, Guangzhou 510515, China |
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| Abstract: | Object To determine the change of glycyrrhizinic acid in different decoctions prepared from various combinations of Gegen Qinlian Decoction (GQD) by RP HPLC. Methods Eight decoctions of Radix Glycyrrhizae Preparata either alone or in combination with one or more of the other three components were prepared and analyzed by L 8(2 7) orthogonal design and statistic analysis (SPSS 10 0). Their glycyrrhizinic acids were determined by RP HPLC. Results For Rhizoma Coptidis, the difference of glycyrrhizinic acids is significant (P<0 05). For Radix Scutellaria and Radix Puerariae, it is insignificant. Interactions between two of three is insignificant too in this experiment. The sedimentation was found in the decoctions contained Radix Glycyrrhizae Preparata and Rhizoma Coptidis. Conclusion The content of glycyrrhizinic acid is reduced by Rhizoma Coptidis. |
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| Keywords: | Gegen Qinlian Decoction (GQD) compatibility glycyrrhizinic acids HPLC |
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