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大黄素、川芎嗪对中分子物质损伤之人胚大脑皮层神经原细胞的影响
引用本文:晏雪生,姜琳,张建军,彭亚琴,明安萍.大黄素、川芎嗪对中分子物质损伤之人胚大脑皮层神经原细胞的影响[J].中草药,2001,32(2):151-152.
作者姓名:晏雪生  姜琳  张建军  彭亚琴  明安萍
作者单位:湖北中医学院附属医院肝病研究所,湖北武汉 430061
摘    要:目的:为探讨中分子物质对大脑皮层神经原细胞的损伤作用,以及大黄素、川芎嗪对抗中分子物质面是保护大脑皮层神经原细胞的作用机制。方法以妊娠30余周合法流产的人胚大脑皮层神经原细菌为模型,以中分子物质为损伤因素,用大黄素、川芎嗪保护此细胞。结果大黄素对中分子物质损伤体外培养的胚大脑皮层神经原细胞有保护作用,而嗪无此作用,结论,大黄素保护大脑皮层神经原细胞的机制可能与破坏中分子物质活性有关,可推大黄治疗尿毒症脑病的机制与大黄素密切相关,而川芎嗪防治尿毒症可能通过其它途径实现,与中分子物质无直接关系。

关 键 词:大黄素  川芎嗪  中分子物质  尿毒症  脑病  神经原细胞培养  中药  试验
文章编号:0253-2670(2001)02-0151-03
收稿时间:2000/8/16 0:00:00
修稿时间:2000年8月16日

Effects of emodin and ligustrazine on neuron cell in human embr yo cerebral cortex injured by medium molecular substances
YAN Xue sheng,JIANG Lin,ZHANG Jian jun,PENG Ya qin and MING An ping.Effects of emodin and ligustrazine on neuron cell in human embr yo cerebral cortex injured by medium molecular substances[J].Chinese Traditional and Herbal Drugs,2001,32(2):151-152.
Authors:YAN Xue sheng  JIANG Lin  ZHANG Jian jun  PENG Ya qin and MING An ping
Institution:Institute of Hepatopathy, Affiliated Hospital of Hubei College of TCM, Wuhan Hubei 430061, China;Institute of Hepatopathy, Affiliated Hospital of Hubei College of TCM, Wuhan Hubei 430061, China;Institute of Hepatopathy, Affiliated Hospital of Hubei College of TCM, Wuhan Hubei 430061, China;Institute of Hepatopathy, Affiliated Hospital of Hubei College of TCM, Wuhan Hubei 430061, China;Institute of Hepatopathy, Affiliated Hospital of Hubei College of TCM, Wuhan Hubei 430061, China
Abstract:
Keywords:emodin  ligustrazine  medium molecular substances  uremia/encephalopathy  neuron/cell culture
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