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安肠胶囊治疗慢性溃疡性结肠炎临床对照观察
引用本文:肖振球,吕小平.安肠胶囊治疗慢性溃疡性结肠炎临床对照观察[J].广西中医药,1997,20(5):7-11.
作者姓名:肖振球  吕小平
作者单位:广西中医学院第二附属医院
摘    要:为探索治疗慢性溃疡性结肠炎的有效药物,用自拟安肠胶囊治疗溃疡性结肠炎100例。并分别用补脾益肠丸、甲硝唑各治疗该病50例,作为对照1组及2组。结果治疗组治愈率为62%,有效率95%,高于对照组(P<0.01)。治疗前后免疫球蛋白测定,治疗组治疗后IgA,IgG,IgM较治疗前明显降低,对照1组IgG,IgM及对照2组仅IgM较治疗前降低。治疗组50例治疗前后肠粘膜活检,治疗后肠粘膜炎症细胞显著减少,肠粘膜的血液循环恢复正常。对治疗组16例进行治疗前后免疫组织化学检查,16例治疗前均有T淋巴细胞阳性反应,治疗后T淋巴细胞减少。提示安肠胶囊具有减轻肠道T淋巴细胞的浸润,降低肠粘膜局部免疫炎症反应及调节机体免疫功能的作用。

关 键 词:溃疡性结肠炎  泄泻  安肠胶囊  中医药疗法  粘膜活检  免疫组织化学检查

Clinical Control Obervation on Treatment of Chronic Ulcerative Colitis with An Chang Capsule
Xiao Zhenqiu L u .. Xiaoping He Zesheng Yin Xueman Xiao Liuhua The Second Affiliated Hospital of GuangXi College of TCM NangJing Rood,Nanning.Clinical Control Obervation on Treatment of Chronic Ulcerative Colitis with An Chang Capsule[J].Guangxi Journal of Traditional Chinese Medicine,1997,20(5):7-11.
Authors:Xiao Zhenqiu L u Xiaoping He Zesheng Yin Xueman Xiao Liuhua The Second Affiliated Hospital of GuangXi College of TCM NangJing Rood  Nanning
Institution:Xiao Zhenqiu L u .. Xiaoping He Zesheng Yin Xueman Xiao Liuhua The Second Affiliated Hospital of GuangXi College of TCM 530011 39 NangJing Rood,Nanning
Abstract:Cases of chronic ulcerative colitis were treated with An Chang Capsule as treating group.50 cases of the same disease were treated with Bu Pi Yi Chang Pill as control group A and another 50 cases were treated with miediling as Control group B.Result:In the treating group the cure rate was 62% ,the response rate was 95%.These results were higher than these of the control groups(P<0.01).The determination of the immunoglobulin before and after treatment showed that IgA,IgG,IgM dropped marrkedly in the treating group,While in Control group A only IgA and IgM dropped and in Control group B only IgM.The biopsy of the enteric mucous of the 50 cases in the treating group before and after etreatment,showed that the inflammatory cells in the enteric mucosae reduced markedly and the blood circulation in the enteric mucosae returned to normal after treatment.The immunohistochemical examination of the 16 cases in the treating group before and after treatment showed that all the cases had positive reaction of the T-lymphocyte, However,after treatment, T-lymphocyte decreased,indicating that An Chang Capsule has the effects of all eviating the infiltration of T-lymphocytes reducing the local immune inflammatory reaction of enteric mucosa,adjusting the immunologic function.
Keywords:Ulcerative colitis  Diarrhea  An Chang Capsule  Therapy of TCM  Biopsy mucosae  Immunohistochemistry
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