| 气不摄血证免疫性血小板减少症患者血管活性物质及相关炎症因子变化与临床意义 |
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| 引用本文： | 王洪志,朱世荣,胡晓梅,王明镜,谌海燕,全日城,丁晓庆,赵攀,范腾,李雨蒙,郭小青,姜云耀.气不摄血证免疫性血小板减少症患者血管活性物质及相关炎症因子变化与临床意义[J].世界科学技术-中医药现代化,2020,22(3):907-912. |
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| 作者姓名： | 王洪志 朱世荣 胡晓梅 王明镜 谌海燕 全日城 丁晓庆 赵攀 范腾 李雨蒙 郭小青 姜云耀 |
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| 作者单位： | 中国中医科学院西苑医院 北京100091;中国中医科学院西苑医院 北京100091;北京中医药大学 北京100029;中国中医科学院西苑医院 北京100091;中国中医科学院研究生院 北京100700;北京中医药大学东方医院 北京100078 |
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| 基金项目： | 立项部门：中华人民共和国科学技术部；项目类型：国家重点基础研究发展计划(973计划）；编号：2015CB554400, 2015CB554403；名称：气不摄血证免疫性血小板减少症的临床研究；负责人：胡晓梅。 |
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| 摘 要： | 目的 本研究旨在探讨气不摄血证免疫性血小板减少症(ITP)患者血管活性物质及相关炎症因子在ITP发病中的作用及其临床意义。方法 气不摄血证ITP患者30例（ITP组），根据2016版ITP出血评分量表,分为未出血组、低危组（≤2分）及高危组（＞2分），健康正常人20例（对照组）。酶联免疫吸附（ELISA）法检测外周血血管活性物质一氧化氮(NO)、一氧化氮合成酶（NOS）及内皮素-1（ET-1）含量，AimPlex流式高通量技术检测外周血血管活性物质VEGF-A,VEGF-D及相关炎症因子IL-8,IL-10,IL-17A以及TNF-α含量。结果 与对照组相比较，气不摄血证ITP患者NOS、VEGF-A及IL-10含量显著降低（P＜0.05)，ET-1、IL-8、IL-17A以及TNF-α含量显著升高（P＜0.05)。同时，气不摄血证ITP患者中，高危组ET-1含量显著高于未出血组（P＜0.05），ET-1、VEGF-A含量与气不摄血证ITP患者出血显著相关（OR=1.012,95%CI:0.92-1.31；OR=1.065, CI:0.98-1.22,P＜0.05)。结论 血管活性物质及相关炎症因子在气不摄血证ITP患者的发病过程中具有重要作用，ET-1、VEGF-A可能是反应气不摄血证ITP患者出血风险的重要客观指标。
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| 关 键 词： | 气不摄血证 免疫性血小板减少症 血管活性物质 炎症因子 |
| 收稿时间： | 2019/2/16 0:00:00 |
| 修稿时间： | 2020/4/16 0:00:00 |
Changes and Clinical Significance of Vasoactive Substances and Related Inflammatory Factors in Patients with Immune Thrombocytopenia with Syndrome of Qi Failing to Keep Blood |
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| Wang Hongzhi,Zhu Shirong,Hu Xiaomei,Wang Mingjing,Chen Haiyan,Quan Richeng,Ding Xiaoqing,Zhao Pan,Fan Teng,Li Yumeng,Guo Xiaoqing and Jiang Yunyao.Changes and Clinical Significance of Vasoactive Substances and Related Inflammatory Factors in Patients with Immune Thrombocytopenia with Syndrome of Qi Failing to Keep Blood[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2020,22(3):907-912. |
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| Authors: | Wang Hongzhi Zhu Shirong Hu Xiaomei Wang Mingjing Chen Haiyan Quan Richeng Ding Xiaoqing Zhao Pan Fan Teng Li Yumeng Guo Xiaoqing and Jiang Yunyao |
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| Institution: | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China,Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;Beijing University of Chinese Medicine, Beijing 100029, China,Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China,Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;Graduate School, China Academy of Chinese Medical Sciences, Beijing 100700, China,Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China,Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China,Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China,Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;Graduate School, China Academy of Chinese Medical Sciences, Beijing 100700, China,Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;Graduate School, China Academy of Chinese Medical Sciences, Beijing 100700, China,Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;Beijing University of Chinese Medicine, Beijing 100029, China,Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China,Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China |
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| Abstract: | |
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| Keywords: | Syndrome of qi failing to control blood immune thrombocytopenia vasoactive substance inflammatory factors |
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