| 生理药代动力学模型在天然药物药动学研究中的应用＊ |
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| 引用本文： | 姚莉,李思泽,李敏,丁宁,相小强. 生理药代动力学模型在天然药物药动学研究中的应用＊[J]. 世界科学技术-中医药现代化, 2020, 22(12): 4147-4153 |
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| 作者姓名： | 姚莉 李思泽 李敏 丁宁 相小强 |
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| 作者单位： | 复旦大学药学院 上海201203 |
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| 基金项目： | 国家自然科学基金;上海市科学技术委员会上海市科技创新行动计划实验动物研究领域项目;国家科技重大专项 |
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| 摘 要： | 生理药代动力学（Physiologically based pharmacokinetic,PBPK）模型是一种基于解剖生理学信息和药物的理化特征,模拟药物在体内各组织器官吸收、分布、代谢、消除过程的数学模型。本文就运用PBPK模型开展的天然药物药动学研究进行综述,从药物相互作用和特殊人群应用方面讨论了PBPK模型的应用与前景,旨在为天然药物的临床前研究和临床使用提供新思路。
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| 关 键 词： | 生理药代动力学 天然药物 药物相互作用 特殊人群 |
| 收稿时间： | 2020-02-29 |
| 修稿时间： | 2021-02-01 |
Application of Physiologically Based Pharmacokinetic (PBPK) Modeling in Pharmacokinetics of Natural Medicine |
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| Yao Li,Li Size,Li Min,Ding Ning and Xiang Xiaoqiang. Application of Physiologically Based Pharmacokinetic (PBPK) Modeling in Pharmacokinetics of Natural Medicine[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2020, 22(12): 4147-4153 |
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| Authors: | Yao Li Li Size Li Min Ding Ning Xiang Xiaoqiang |
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| Affiliation: | School of Pharmacy, Fudan University, Shanghai 201203, China,School of Pharmacy, Fudan University, Shanghai 201203, China,School of Pharmacy, Fudan University, Shanghai 201203, China,School of Pharmacy, Fudan University, Shanghai 201203, China,School of Pharmacy, Fudan University, Shanghai 201203, China |
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| Abstract: | Physiologically based pharmacokinetic modeling is a kind of mathematics modeling technique that simulates the absorption, distribution, metabolism and elimination of drugs in various tissues and organs in vivo based on physiological and anatomical characteristics and physicochemical properties of drugs. This review summarizes the pharmacokinetic studies of natural medicine components using PBPK model and discusses the application and potential of PBPK modeling from the drug-drug interaction and application in special populations for natural medicine. This paper aims to provide a novel strategy for the preclinical research and clinical use of natural medicine. |
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| Keywords: | Physiologically based pharmacokinetic Natural medicine Drug-drug interaction Special population |
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