冠心病痰瘀证客观指标的临床研究

目的：探讨冠心病痰瘀证与多个客观指标的相关性，为冠心病痰瘀证的临床研究提供依据。方法：将120 例冠心病患者分为痰瘀证组（76 例）和非痰瘀证组（44 例），另选择体检健康者20 例设为正常对照组，从血脂、糖代谢、炎症因子等方面进行比较和统计学分析。结果：痰瘀证组在总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、血胰岛素（FINS）、超敏C 反应蛋白（hs-CRP）、基质金属蛋白酶-9（MMP-9）水平方面均明显高于正常对照组及非痰瘀证组（P<0.05 或P<0.01）。结论：TC、TG、LDL-C、FINS、hs-CRP、MMP-9 水平可为冠心病痰瘀辨证分型提供客观依据。

Clinical Study on Objective Indexes of Phlegm-stasis Syndrome of Coronary Heart Disease

This study was aimed to explore the correlation between the phlegm -stasis syndrome of coronary heart disease (CHD) and multiple objective indexes in order to provide the basis for clinical study of phlegmstasis syndrome of CHD. A total of 120 patients were divided into the phlegm -stasis syndrome group (76cases) and the non -phlegm -stasis syndrome group (44 cases). And 20 cases of healthy volunteers were selected as the normal control group. Comparison and statistical analysis were made from aspects of blood lipids, glucose metabolism, inflammation factor and etc. The results showed that the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), fasting insulin (FINS), hypersensitive Creactive protein (hs-CRP), matrix metalloproteinase-9 (MMP-9) in the phlegm-stasis syndrome group were significantly higher than those in the normal control group and the non-phlegm-stasis syndrome group (P <0.05, or P < 0.01). It was concluded that the levels of TC, TG, LDL-C, FINS, hs-CRP and MMP-9 can provide objective basis for the phlegm-stasis syndrome of CHD.