| 滋补脾阴方药对脾阴虚痴呆大鼠脑组织内质网应激影响的研究 |
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| 引用本文： | 战丽彬,林海燕,宫晓洋,刘莉,梁丽娜.滋补脾阴方药对脾阴虚痴呆大鼠脑组织内质网应激影响的研究[J].世界科学技术-中医药现代化,2011,13(6):993-998. |
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| 作者姓名： | 战丽彬 林海燕 宫晓洋 刘莉 梁丽娜 |
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| 作者单位： | 大连医科大学附属二院中医科，大连医科大学中西医结合研究院;大连市第六人民医院中医科;大连医科大学附属一院中医科;大连大学附属中山医院急诊科;大连医科大学附属二院中医科 |
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| 基金项目： | 教育部高等学校博士学科点专项科研基金资助课题（20070161004）：脾阴虚痴呆与糖尿病脑病的内质网应激机制研究，负责人：战丽彬。 |
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| 摘 要： | 目的:观察滋补脾阴方药(ZBPYR)对脾阴虚痴呆大鼠不同脑区内质网应激的影响.方法:通过证病结合的方法建立脾阴虚痴呆大鼠模型,以免疫组化方法检测各组大鼠海马(CA1、CA3、DG区)、大脑皮质中内质网应激相关分子葡萄糖调节蛋白78( GRP78)、凋亡促进因子CCAAT/增强子结合蛋白同源蛋白(CHOP)的表达变化.结...
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| 关 键 词： | 阿尔茨海默病 脾阴虚痴呆 滋补脾阴方药 内质网应激 葡萄糖调节蛋白78CCAAT/增强子结合蛋白同源蛋白 |
| 收稿时间： | 2010/11/16 0:00:00 |
| 修稿时间： | 2011/12/18 0:00:00 |
Effects of Zibu Piyin Recipe on Endoplasmic Reticulum Stress in Brain Tissue of Spleen-Yin Deficiency Alzheimer's Disease Rats |
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| Zhan Libin,Lin Haiyan,Gong Xiaoyang,Liu Li and Liang Lina.Effects of Zibu Piyin Recipe on Endoplasmic Reticulum Stress in Brain Tissue of Spleen-Yin Deficiency Alzheimer''s Disease Rats[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2011,13(6):993-998. |
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| Authors: | Zhan Libin Lin Haiyan Gong Xiaoyang Liu Li and Liang Lina |
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| Institution: | 1. Department of Traditional Chinese Medicine, the Second Affiliated Hospital of Dalian Medical University,Dalian 116023, China;2. Department of Traditional Chinese Medicine, the Sixth People's Hospital of Dalian, Dalian 116001, China;3. Department of Traditional Chinese Medicine, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;4. Department of Emergency, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China;5. Academy of Integrative Medicine of Dalian Medical University, Dalian 116044, China |
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| Abstract: | Effects of Chinese herbs for Zibu Piyin Recipe (ZBPYR) on spleen-yin deficiency Alzheimer's Disease (AD) rats were investigated. A new rat model was established with both AD and spleen-yin deficiency syndrome. Then, expressions of protein in hippocampus (CA1, CA3, DAG region), and proteins correlated to endocytoplasmic reticulum stress, glucose regulated protein78 (GRP78), CCAAT/EBP homologous protein (CHOP) of cerebral cortex were determined. The results showed that contrasted with two AD groups, the expression of GRP78 protein was upregulated obviously (P < 0.05) in the ZBPYR group. And the expression of CHOP protein was down-regulated obviously (P< 0.05). It is concluded that Chinese herbs for ZBPYR improve the ability of learning and memory by reinforcing the survival pathway of ERS, and inhibiting the apoptosis pathway of ERS. |
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| Keywords: | Alzheimer's disease Spleen -Yin deficiency Alzheimer's disease Zibu Piyin Recipe endoplasmic reticulum stress glucose regulated protein78 CCAAT/EBP homologous protein |
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