支气管哮喘慢性持续期中医临床表型探索

目的：探索并总结支气管哮喘慢性持续期的中医辨证分型，以期为有机结合临床中医证候特征、哮喘临床表型以及基因组学的研究提供可借鉴的依据。方法：采用回顾性文献调研与临床流行病学调查相结合的方法，通过文献调研及分析和预调查反馈信息修正的方法，设计并归纳形成支气管哮喘慢性持续期中医证候学观察表。收集204例患者的四诊资料，填写观察表。借助SPSS22统计分析软件建立数据库,应用系统聚类分析的方法,归纳出支气管哮喘慢性持续期基本的中医证型。结果：通过对观察指标进行统计分析，结合中医哮病的辨证标准为依据，参阅哮病中医证候规律的文献，并组织呼吸科专家讨论，得出支气管哮喘慢性持续期主要分为2个基本证候:虚寒证和虚热证。结论：探索了支气管哮喘慢性持续期中医临床表型，为进一步研究支气管哮喘中医宏观寒热辨证与西医基因组学之间可能的关联提供研究数据。

Exploration of Traditional Chinese Medicine Clinical Phenotype in Chronic Persistent Bronchial Asthma

This study was aimed to explore and summarize traditional Chinese medicine (TCM) syndrome differentiation of chronic bronchial asthma, in combination with characteristics of clinical TCM syndrome, clinical phenotype of asthma and the research of genomics in order to provide references. This study was conducted by the method of combining retrospective literature research and clinical epidemiological survey, designing and inducing the formation of chronic duration of bronchial asthma in TCM syndrome observation table, through literature research and analysis and pre-survey feedback information revision method. The four diagnostic data of 204 cases was collected and filled in the observation table. With the help of SPSS22 statistical analysis software, the database was established and the method of cluster analysis was applied to induce the basic TCM syndrome types of chronic bronchial asthma. The results showed that bronchial asthma chronic persistent period was divided into two basic syndromes, which were the cold- deficiency syndrome and heat- deficiency syndrome. It was concluded that the clinical phenotype of bronchial asthma chronic duration was explored for further research on the relationship between TCM syndrome differentiation of cold and heat as well as the modern medicine genomics to provide research data.