| 蚓激酶的药理作用研究进展＊ |
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| 引用本文： | 夏梦瑶,李艳灵,魏艳平,孙鹏,冯玉,魏永利.蚓激酶的药理作用研究进展＊[J].世界科学技术-中医药现代化,2021,23(12):286-292. |
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| 作者姓名： | 夏梦瑶 李艳灵 魏艳平 孙鹏 冯玉 魏永利 |
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| 作者单位： | 山东中医药大学药学院 济南 250355,山东中医药大学药学院 济南 250355,山东中医药大学药学院 济南 250355,山东中医药大学药学院 济南 250355,山东中医药大学药学院 济南 250355,山东中医药大学附属医院 济南 250014 |
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| 基金项目： | 国家自然科学基金委员会面上项目（81874419）：ATP/P2X7R-NLRP3炎性小体通路介导的神经可塑受损在肝疏泄失常怒情志中的作用及机制研究，负责人：孙鹏；山东省卫生健康委员会重点研发计划（2018GSF119022）：医疗机构制剂“四虫胶囊”的研制，负责人：魏永利。 |
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| 摘 要： | 蚓激酶，是从蚯蚓（地龙）中提取的一种蛋白水解酶，具有良好的纤维蛋白溶解活性，在抗血栓及缺血性心脑血管疾病中有着较好的疗效。目前开发的蚓激酶纳米靶向给药系统或蚓激酶与其他药物的联合应用，可进一步提高蚓激酶的生物利用度和安全性，已广泛应用于溶栓、抗肿瘤等疾病的治疗，疗效显著。本文就蚓激酶的相关组分及蚓激酶在溶栓、心脑血管、抗肿瘤、心脑血管保护等方面的药理作用进行综述，为其进一步的开发利用提供依据。
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| 关 键 词： | 蚓激酶 纳米靶向 药理作用 研究进展 |
| 收稿时间： | 2021/1/22 0:00:00 |
| 修稿时间： | 2021/12/11 0:00:00 |
Research Progress on Pharmacological Effects of Lumbrokinase |
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| Xia Mengyao,Li Yanling,Wei Yanping,Sun Peng,Feng Yu and Wei Yongli.Research Progress on Pharmacological Effects of Lumbrokinase[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2021,23(12):286-292. |
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| Authors: | Xia Mengyao Li Yanling Wei Yanping Sun Peng Feng Yu and Wei Yongli |
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| Institution: | School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China,School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China,School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China,School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China,School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China,The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China |
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| Abstract: | Lumbrokinase is a proteolytic enzyme extracted from earthworms (Lumbricus). It has good fibrinolytic activity and has a good effect on anti-thrombosis and ischemic cardiovascular and cerebrovascular diseases. The currently developed lumbrokinase nano-targeted drug delivery system or the combined application of lumbrokinase and other drugs can further improve the bioavailability and safety of lumbrokinase. It has been widely used in the treatment of thrombolytic, anti-tumor and other diseases with significant curative effect. This paper reviewed the related components of lumbrokinase and the pharmacological effects of lumbrokinase in throm-bolysis, cardio-cerebrovascular, anti-tumor, cardio-cerebrovascular protection, etc., to provide a basis for its further development and utilization. |
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| Keywords: | Lumbrokinase Nano targeting Pharmacological effect Research progress |
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