痛情绪相关神经递质及神经环路研究进展＊

痛情绪是指因疼痛引发的情绪和情感体验,是疾病过程中最常见的一种情绪。痛情绪相关神经机制非常复杂,但主要与单胺类神经递质、神经肽和某些神经环路有关,笔者将结合目前研究现状分别从以上两方面展开,就痛情绪相关单胺类神经递质和神经肽在受体分类、脑区通路、共疾病以及各神经递质之间的联系和痛情绪相关神经环路中各个蛋白的作用机制等方面进行探讨。

Advances in research on neurotransmitters and neurochids related to pain emotion

Pain emotions are an emotional and emotional experience caused by pain, which is the most common emotion in the disease process. The pain-related neurological mechanism is very complicated, but mainly related to monoamine neurotransmitter, neuropeptide and certain neural loops. Based on the current research status, the author will start from the above two aspects, and discuss the relationship between pain emotion-related monoamine neurotransmitters and neuropeptides in receptor classification, brain region pathways, co-diseases, and the relationship between neurotransmitters and pain emotion, as well as the mechanism of action of each protein in the neural circuit.