慢性乙型肝炎及其肝炎后肝硬化中医证候分类的系统生物学研究

中医对慢性肝病的诊疗特色和优势体现于在证候分类基础上进行个体化治疗。本文对慢性乙型肝炎(乙肝)及其肝炎后肝硬化中医证候分类进行系统生物学研究,探讨其证候分类与基因多态性的关联、基因和蛋白表达谱的区别、尿代谢物的差异以及"同病异证"、"异病同证"的分子机制。结果显示乙肝及其肝炎后肝硬化中医证候分类具有分子生物学物质基础;基于系统生物学的中医证候判别方法可有助于形成乙肝及肝炎后肝硬化新的分类,并为乙肝及肝炎后肝硬化的诊断和个体化治疗提供参考依据。

Application of Systems Biology in TCM Syndrome Classification of Chronic Hepatitis B and Posthepatitic Cirrhosis

The characteristics and advantages of traditional Chinese medicine (TCM) diagnosis and treatment of chronic liver diseases are conducted on the individualized treatment based on TCM syndrome classification. In this study, the analysis of systems biology was carried out for TCM syndrome classification in chronic hepatitis B and posthepatitic cirrhosis. The relationship between TCM syndrome classification and genetic polymorphism, the difference of genes and protein expression profiles, the difference of urine metabolite, and the molecular mechanism of "Different TCM Syndrome for Same Disease" and "Same TCM Syndrome for Different Diseases" were discussed. The results showed that there are molecular biological basis in TCM syndrome classification in hepatitis B and posthepatitic cirrhosis. The systems biology based syndrome identification methods may be beneficial to form a new classification, and provide reference for the diagnosis and individual therapy of hepatitis B and posthepatitic cirrhosis.