解毒通脉汤干预闭塞性动脉硬化症及对ABI、CRP、TCPO2 的影响

目的：观察解毒通脉汤治疗闭塞性动脉硬化症的临床疗效。方法：选取246 例闭塞性动脉硬化症患者中血脉瘀阻型患者，随机分成两组，对照组120 例，患者常规口服拜阿司匹林0.1 g+辛伐他丁片20 mg，每日一次；治疗组126 例，患者在口服拜阿司匹林及辛伐他丁片的基础上，加服中药解毒通脉汤，8 周后观察患者临床症状改善情况和臂踝指数（ABI）、超敏C 反应蛋白（Hs-CRP）、持续经皮氧分压（TcPO2）变化。结果：与对照组相比，治疗组临床症状明显改善（P＜0.05），患者ABI、CRP、TcPO2 均有显著提高（P＜0.01）。结论：解毒通脉汤对闭塞性动脉硬化症血脉瘀阻型患者治疗有效，间接验证了中医因邪致瘀理论的指导意义。

Treatment of Arteriosclerosis Obliterans with Jie-Du Tong-Mai Decoction and Influence on ABI, CRP, TCPO2

This study was aimed to observe the clinical efficacy of Jie-Du Tong-Mai (JDTM) decoction (i.e., detoxification unclogg artery soup) of arteriosclerosis obliterans. A total of 246 arteriosclerosis obliterans cases with the pattern of blood stasis were selected and randomly divided into two groups. In the control group of 120 cases, 0.1 g of aspirin and 20 mg of simvastatin tablets were orally administrated, once a day. In the treatment group of 126 cases, JDTM decoction was combined on the basis of oral administration of aspirin and simvastatin tablets. After 8 weeks of treatment, observations were made on improvement of clinical symptoms and changes of ABI, Hs-CRP,TcpO2. The results showed that compared with the control group, clinical symptoms of the treatment group were obviously improved (P < 0.05). And the ABI, CRP, TcpO2 were also obviously increased (P < 0.01). It was concluded that JDTM decoction was effective in the treatment of arteriosclerosis obliterans with the pattern of blood stasis. It also indirectly proved the guiding meaning of traditional Chinese medicine that evil causing stasis.