首页 | 本学科首页   官方微博 | 高级检索  
检索        

星座药理学与中药研究
引用本文:谢伟东,蒋鑫,雷帆,徐晨珂,赵玉男,杜力军.星座药理学与中药研究[J].世界科学技术-中医药现代化,2016(6):1012-1017.
作者姓名:谢伟东  蒋鑫  雷帆  徐晨珂  赵玉男  杜力军
作者单位:清华大学深圳研究生院生命与健康学部健康科学与技术重点实验室 深圳 518055,清华大学深圳研究生院生命与健康学部健康科学与技术重点实验室 深圳 518055,清华大学药学院 北京 100084,清华大学深圳研究生院生命与健康学部健康科学与技术重点实验室 深圳 518055,南京中医药大学基础医学院病理教研室 南京 210046,清华大学生命科学院药物药理实验室 北京 100084
基金项目:国家自然科学基金委面上项目(81373460):基于ceRNA与miRNA“网络对话”研究胰岛细胞炎症“微环境”与功能及探索抗糖尿病药物新策略,负责人:谢伟东。
摘    要:星座药理学是一种基于细胞表型的高内涵药物筛选新方法,该方法主要根据关键信号蛋白、特定表型的细胞群,将多种药物在这些细胞上的作用情况整合成具有特定药理调节功能的药物组合和细胞星座,强调这些细胞之间能进行病理、生理功能上的有机组合与整体联系。基于不同分子靶点的药物组合,进行特定的药理调控,形成药理意义上的星座效应。星座药理学的运用可提高整体疗效、减少不良反应及药物的耐受性。星座药理学适合中药等复杂成分群在细胞水平进行活性筛选与功能评价,在中药新药研究方面具有较大的灵活性与创新活力,因而对于创新中药研究与开发具有积极的推动作用。

关 键 词:星座药理学  协同作用  中药  细胞实验
收稿时间:2016/5/25 0:00:00
修稿时间:2016/6/14 0:00:00

Constellation Pharmacology and Researches on Traditional Chinese Medicine
Xie Weidong,Jiang Xin,Lei Fan,Xu Chenke,Zhao Yunan and Du Lijun.Constellation Pharmacology and Researches on Traditional Chinese Medicine[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2016(6):1012-1017.
Authors:Xie Weidong  Jiang Xin  Lei Fan  Xu Chenke  Zhao Yunan and Du Lijun
Institution:Shenzhen Key Laboratory of Health Science and Technology,Division of Life Science&Health,Graduate School at Shenzhen,Tsinghua University,Shenzhen 518055,China,School of Pharmacology and Pharmaceutical Sciences,Tsinghua University,Beijing 100084,China,Laboratory of Pathological Sciences,Basic Medical College,Nanjing University of Traditional Chinese Medicine,Nanjing 210046,China and Laboratory of Molecular Pharmacology and Pharmaceutical Science,School of Life Science,Tsinghua University,Beijing 100084,China
Abstract:Constellation pharmacology is a cell-based high-content phenotypic-screening platform that investigate effects of drug cabal in cells with key signaling proteins which define specific cell types and further integrate into cell constellation with pharmacological functions.Constellation pharmacology emphasizes on organic combinations and whole connections between different subtype cells with pathophysiological significance,in which drug cabal with different molecular targets can produce specific synergic pharmacological effects in the cell constellation.The utilization of constellation pharmacology will promote therapeutic effects,while reduce untoward effects and drug tolerances. Constellation pharmacology can be applied in the field of pharmacological evaluation of complicated compounds in traditional Chinese medicines at the level of cells,and have much flexibility and innovative vitality in the research and development of traditional Chinese medicines. Therefore,constellation pharmacology may proactively promote the research and development of novel traditional Chinese medicine.
Keywords:Constellation pharmacology  synergic action  traditional Chinese medicines  cellular experiments
点击此处可从《世界科学技术-中医药现代化》浏览原始摘要信息
点击此处可从《世界科学技术-中医药现代化》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号