电针对脑局部缺血再灌流大鼠SEP的影响

利用Wistar大鼠，采用线检法闭塞大脑中动脉建立可逆性局灶性脑缺血再灌流动物模型，通过病理、生理的检测，观察电针“环跳”穴对脑缺血再灌流大鼠的治疗和保护作用。结果表明，脑缺血3小时后大鼠胫神经刺激记录的大脑皮层体感诱发电住（SEP）之P1-N1波幅明显降低，P1和N1峰潜伏期明显延长；拔出线栓造成再灌流2小时后，SEP的各异常参数均未见好转，提示缺血损伤后的皮层及皮层下神经元又受到再灌流损伤而发生了不可逆性改变。对大脑进行的组织学切片染色结果显示梗塞灶位于尾状核及大脑半球外侧皮质。而于缺血后期进行“环跳”穴电针处理的大鼠，SEP各异常成份均有较好的恢复，并保持到再灌流2小时，与正常大鼠的检测结果相近。提示针刺对脑组织的缺血性损伤具有明显的治疗作用，并对再灌流的损伤具有预置性保护作用；认为针刺的效应是对机体全身各系统的功能进行综合性、良性调整的结果。

The Effect of Electric Acupuncture on SEP of Local Cerebral Ischemic-Reperfusion Rats

The results suggest that 3 hours after cerebral ischemia, the P1- N1 amplitudes of the somatosensory evoked potential (SEP) of the cerebral coriex decrease significantly by the stimulation of cerebrum, while the latency period of both wave P1 and P2 prolonged; 2 hours later, the abnormal data of SEP have not any improvement. These suggest that the post-ischemic cortex and subcortical neurons were injured permanently by a substantial lesions from reperfusional injuries. Cerebral tissue histologic studies show that the infarcted focus locates in caudate nucleus and lateral cortex of cerebral hemisphere. But after electric acupunctrue at Huantiao at the late stage of cerebral ischemia of rats, the abnormal data of SEP show better recoveries and manintains till 2 hours after reperfusion, and even near to that of the normal rat. All of them suggest acupunctrue is effective obviously for ischemic injury of cerebral ussue, and possesses a presetting protection for reperfusional injury of cerebral tissue. So it is concluded that the efficacy of acupuncture results frtm its comprehensive and optimal regulation function to multisystem of the whole body