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针刀松解法对第三腰椎横突综合征大鼠血管活性物质的影响
引用本文:郭长青,刘乃刚,李晓泓,孙红梅,卢婧,马惠芳,陈占禄,胡波,刘琳,朱汉章.针刀松解法对第三腰椎横突综合征大鼠血管活性物质的影响[J].针刺研究,2007,32(5):323-326.
作者姓名:郭长青  刘乃刚  李晓泓  孙红梅  卢婧  马惠芳  陈占禄  胡波  刘琳  朱汉章
作者单位:1. 北京中医药大学针灸学院
2. 北京中医药大学解剖教研室,北京,100029
基金项目:国家重点基础研究发展计划(973计划)
摘    要:目的:探讨针刀松解法对第三腰椎横突综合征模型大鼠的治疗机制。方法:将40只SD大鼠随机分为正常组、模型组、电针组和针刀组4组,每组10只。后3组首先采用在第三腰椎横突尖部埋置明胶海绵的方法制作第三腰椎横突综合征模型,电针组和针刀组分别给予电针患侧"肾俞"腰阳关"和针刀松解干预治疗。造模后第28天,应用放射免疫分析法和酶联免疫分析法观察4组动物血中降钙素基因相关肽(CGRP)、内皮素(ET)、6-酮-前列腺素F1α(6-keto-PGF1α)、血栓素A2(TXA2)含量的变化。结果:模型组大鼠血浆中ET、CGRP、TXA2、6-keto-PGF1α含量与正常组比较均呈上升趋势(P<0.01);经电针和针刀松解法治疗后,血浆中ET含量与模型组比较差异无显著性意义(P>0.05),CGRP、TXA2、6-keto-PGF1α含量较模型组明显降低(P<0.05,0.01);电针组与针刀组比较,除TXA2含量两者差异有显著性意义外,其余3项指标两组间差异无显著性意义。结论:针刀松解法对第三腰椎横突综合征大鼠血管活性物质的合成与分泌具有良性调节作用,使其恢复到正常水平,从而使炎症局部循环障碍得到改善。

关 键 词:针刀松解法  第三腰椎横突综合征  血管活性物质
文章编号:1000-0607(2007)05-0323-04
收稿时间:2007-05-30
修稿时间:2007年5月30日

Effect of Lysis of Acupotomology on Plasma Vasoactive Substance Levels in Rats with Third Lumbar Vertebra Transverse Process Syndrome
GUO Chang-qing,LIU Nai-gang,LI Xiao-hong,SUN Hong-mei,LU Jing,MA Hui-fang,CHEN Zhan-lu,HU Bo,LIU Lin,ZHU Han-zhang.Effect of Lysis of Acupotomology on Plasma Vasoactive Substance Levels in Rats with Third Lumbar Vertebra Transverse Process Syndrome[J].Acupuncture Research,2007,32(5):323-326.
Authors:GUO Chang-qing  LIU Nai-gang  LI Xiao-hong  SUN Hong-mei  LU Jing  MA Hui-fang  CHEN Zhan-lu  HU Bo  LIU Lin  ZHU Han-zhang
Institution:1.College of Acu-moxibustion , Beijing University of Chinese Medicine, Beijing 100029, China; 2. Department of Anatomy, Beijing University of Chinese Medicine, Beijing 100029
Abstract:OBJECTIVE: To observe the effect of small needle-knife lysis on plasma calcitonin gene-related peptide (CGRP), endothelin (ET), 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha), thromboxane A2 (TXA2) contents in rats with experimental third lumbar vertebra transverse process syndrome (TLVTPS) so as to explore its underlying mechanism in clinical treatment. METHODS: Forty SD rats were randomly divided into normal control, model, lysis and EA groups. TLVTPS model was established by embedding a piece of gelatin sponge (0.5 cm x 0.5 cm) to the transverse process of the 3rd lumbar vertebra under anesthesia. EA (2/100 Hz, 1-2 mA) was applied to left "Shenshu" (BL23) -"Yaoyangguan" (GV3) for 20 min, once every other day, 6 times altogether. For animals of lysis group, the lysis was performed by using a small needle-knife in the induration spot or cord-like region near the incision, once a week and twice altogether. Four weeks later after modeling, plasma CGRP, ET, 6-keto-PGF1alpha and TXA2 contents were detected by using radioimmunoassay and enzyme linked immunosorbent assay (ELISA). RESULTS: Compared with normal control group, plasma CGRP, ET, TXA2 and 6-keto-PGF1alpha increased significantly in model group (P<0.01); in comparison with model group, plasma CGRP, TXA2 and 6-keto-PGF1alpha in both EA and lysis groups decreased considerably (P<0.05, 0.01). No significant differences were found between EA and lysis groups in plasma CGRP, ET and 6-keto-PGF1alpha levels (P>0.05). CONCLUSION: Both EA and lysis of acupotomology have an adjusting effect on vasoactive substances (CGRP, TXA2 and 6-keto-PGF1alpha) levels in TLVTPS rats, which may contribute to their effects in improving local blood circulation and relieving soft tissue injury in the treatment of third lumbar vertebra transverse process syndrome.
Keywords:Lysis of acupotomology  Third lumbar vertebra transverse process syndrome  Vasoactive substances
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