电针对糖尿病性认知功能障碍患者学习记忆的影响

目的:观察电针对糖尿病性认知功能障碍患者学习记忆的改善作用,并与尼莫通作对照。方法:将45例符合诊断标准的患者随机分为电针组25例,对照组20例。电针组取四神聪、百会、风池、本神、内关为主穴,电针为疏密波,频率14~26次/min,强度3~5 mA,每次治疗30 min,每日1次,连续5 d后休息2 d,共6周。对照组口服尼莫通,每次30 mg,每日3次,连续治疗6周。对两组治疗前后进行长谷川痴呆修改量表评分及韦氏记忆量表(WMS)评定。结果:两组疗效的差异具有显著性意义,电针组疗效优于对照组;治疗前两组WMS(总记忆商)无显著差异,P>0.05,治疗后电针组WMS评分明显上升,P<0.05,而对照组虽然也有上升,但不显著,P>0.05。电针组治疗后WMS在顺数、联想、触摸方面有显著上升,P<0.05;而对照组WMS在累加、触摸方面有显著上升,P<0.05;其余各项两组均表现为治疗前后差异不显著,P>0.05。结论:电针能改善糖尿病性认知功能障碍患者的认知功能和学习记忆能力。

Influence of Electroacupuncture on Learning and Memory Ability in Diabetic Cognitive Dysfunction Patients

Objective: To observe the effect of electroacupuncture(EA) on the learning and memory ability in diabetic cognitive dysfunction patients.Methods: Forty-five cases of diabetic mellitus(DM) patients with cognitive dysfunction were randomly divided into EA group(n=25) and medication group(n=20).For patients of EA group,main acupoints as Sishenchong(EX-HN 1),Baihui(GV 20),bilateral Fengchi(GB 20), Benshen(GB 13) and Neiguan(PC 6) were punctured with filiform needles and stimulated electrically by setting the stimulating parameters being dense-sparse waves,frequency of 14-26 pulses/min,strength of 3-(5 mA) and duration of (30 min).The treatment was conducted once daily,5 times a week and continuously for 6 weeks.Patients of medication group were ordered to take Nimotop((30 mg)/time),3 times everyday and continuously for 6 weeks.Modified Hastgawa Dementia Scale(HDS) and Wilson's Memory Scale(WMS) were used to evaluate the patients' cognitive function,memory ability and general conditions before and after the treatment.Results: After the treatment,according to HDS, of the 20 and 25 cases in medication and EA groups,1(5%) and 4(16%) experienced marked improvement,5(25%) and 15(60%) had moderate improvement,10(50%)and 5(20%) had mild improvement,and 4(20%) and 1(4%) had no improvement, with the total effective rates being 80% and 96% respectively.Rank test showed that the therapeutic effect of EA group was significantly superior to that of medication group(P<0.05) in improving patients' cognitive function.Self-comparison indicated that WMS of both groups increased significantly after the treatment(P<0.001,0.05),including adding test of long-term memory and touching test of short-term memory in medication group,counting-down test of long-term memory,association test and touching test of short-term memory in EA group;and the effects of EA were apparently superior to those of medication in raising WMS(MQ),counting-down test and association test(P<0.05,0.01).Conclusion: The therapeutic effect of EA is significantly superior to that of Nimotop in improving DM patients' cognitive function,learning and memory ability.