血浆亮氨酸脑啡肽样物质与痛及镇痛的关系

<正> 脑啡肽(EK)自1975年发现以来,不少研究已证明它参与镇痛作用,如当针刺镇痛时脑内及脑脊液中EK含量均升高。由于EK易被降解,因而在测定血浆内含量变化方面报道甚少。本文应用放射免疫法测定人体血浆中亮氨酸脑啡肽(LEK)样物质的含量,并试图探讨其与疼痛及镇痛的关系。对象与方法 (一)对象 1.正常人:11人均系本室健康的工作人员。男6人,女5人。年龄26～52岁。 2.病人:各种疼痛病人32例,男性

PLASMA LEU--BNKEPHALIN (LEK) ANDCLINICAL PAIN

32 patients with various pain perception, before and after acupuncture or operation, had been detected on plasma LEK. It revealed that: (1) the plasma LEK level (8:00-9:00) of patients with acute and severe pain were significantly lower than that of normal subjects. After relief of pain by either acupuncture or operation, the plasma LEK contents in mean value are increased significantly. (2) the plasma LEK level of patients with extration of nucleus pulposus were also lower than that of normal subjects, however, there were no obvious changes after acupuncture. (3) there were no any changes before and after acupuncture in normal subjects. This results suggested that plasma LEK might play an important role in the mechanism of pain perception and analgesia.