经络活动与外周经脉线上钙离子相关性的研究(英文)

本文是天津中医学院针灸系承担的国家攀登计划──经络研究项目的部分总结。以离子选择性针型钙离子电极在体监测发现，人体、家兔经穴处的钙离子浓度有高于非穴位的趋势，针刺可使本经其它穴位处钙离子浓度升高。当脏腑病变时，其相应的经脉线上的钙离子浓度明显下降，而且下降幅度与脏腑病变的程度呈相关关系，有一定的特异性。当络合针刺部位或相应经脉线上的钙离子后，针刺治疗脏腑病变的效应消失，使针刺疗效丧失的络合剂EDTA的最低浓度为10－3mol/L，升高经穴处的钙离子浓度对针效似无影响。进一步实验发现，当阻断针刺穴位或相应经脉线上的细胞膜上的电压门控性钙离子通道、钙调素活性时，针刺经穴治疗脏腑病变的效应消失，提示钙离子与经脉活动密切相关，是针效产生、经络活动的关键因素之一。

The Correlative Study between Activity of Meridians and Collaterals and Ca~(2 ) in Peripheric Meridians

This is a part summarize of research works we take in charge of - The research of the meridians, one of the Nation Climb Plans. Study use the Ca2 selective needle-shaped electrodes, we found that the concentration of Ca2 in the acupoints has a tendency that higher than that in the nonacupoints, and acupuncture one of the acupoints can make it increase of the Ca2 concentration in acupoints along the same meridian. When organ disease occurred, the Ga2 concentration in points along the corresponding meridians decreased markedly and the extent of the extent of the decrease has some thing with that of the organ disease relatively and specifically. When Ca2 in the acupunctured points and points along the same meridians was complexed, acupuncture has no effects to the organ disease.The lowest concentration of EDTA whig the Ca2 concentration in the acupoints has no influence to the effects of acupuncture. The deeply research indicated that when the voltage-gated Ca2 channel and the activity of CaM on the cell membrane in acupoints or points along the meridians was blocked,acupuncture has no effects to the organ diseases. It indicated that Ca2 has something with the activity of the meridians relatively and closely, and the Ca2 is one of the key factors to the effects of acupuncture and the activity of the meridians.