复方亚甲蓝液有氧穴位注射治疗疱疹后神经痛的临床研究

目的:观察复方亚甲蓝液有氧穴位注射治疗疱疹后神经痛(PHN)的临床疗效。方法:80例PHN患者随机分为治疗组和对照组各40例,治疗组用复方亚甲蓝液有氧穴位注射,对照组采用针刺治疗。结果:治疗组痊愈32例,显效6例,有效1例,无效1例,总有效率97.5%(95%CI=97.4%~97.6%);对照组痊愈3例,显效7例,有效19例,无效11例,总有效率72.5%(95%CI=72.3%~72.7%)。治疗组综合疗效显著高于对照组(U=6.33642,P<0.001);治疗组发生无效患者的危险性降低(RR=1.345,95%CI=1.103~1.639;RRR=-34.5%,95%CI=-10.3%~-63.9%);治疗组每治疗4人,可较对照组减少1例无效患者(NNT=4,95%CI=2.5~9.7)。治疗组痊愈患者明显优于对照组(RBI=9.67,95%CI=7.636~11.894;ABI=72.5%,95%CI=72.33%~72.67%);治疗组每治疗1.379人,可较对照组减少1例无痊愈患者(NNT=1.379,95%CI=1.111~1.657)。结论:复方亚甲蓝液有氧穴位注射治疗PHN临床疗效优于常规针刺治疗。

Clinical Observation on the Therapeutic Effect of Acupoint Injection of Compound Methylthioninum Chloride for Post-herpetic Neuralgia

Objective: To observe clinical therapeutic effect of acupoint injection of compound Methylthioninum Chloride(CMC) for treating post-herpetic neuralgia(PHN).Methods: Eighty PHN patients were divided into treatment group(n=40)and control(acupuncture) group(n=40)with random number table method.For patients in treatment group,CMC injection((10 mL)) composed of 0.5% Bupivacaine Hydrochloride((3 mL)),Triamcinolone injection((15 mg)),VitB_(12)(1 mg),VitB_6 injection((100 mg)),CMC((0.02 mg)) and normal saline((3 mL)) was injected into back-shu-points on the first lateral line of the Bladder Meridian and its upper and lower back-shu-points according to the location of herpes zoster,2-(3 mL/point),followed by injecting oxygen((10 mL)) into the same point slowly,once every week,3 times altogether.For patients of control group,the same back-shu points were used and punctured with filiform needles,combined with acupuncture of Zhigou(TE 6),Yanglingquan(GB 34),etc.,once daily,continuously for 3 weeks.Results: Self-comparison showed that after the treatment 6-point-behavoral rating scale(BRS-6) scores of two groups both decreased significantly(P<0.001),and the BRS-6 score of treatment group was significantly lower than that of control group(P<0.01).Of the 40 cases in treatment and control groups,32(80%) and 3(7.5%) cases were cured,6(15.0%) and 7(17.5%) markedly effective,1(2.5%) and 19(47.5%) effective,1(2.5%) and 11(27.5%) failed,with the total effective rates being 97.5% and 72.5% respectively.The therapeutic effect of treatment group was significantly superior to that of control group(P<0.001).Conclusion: The therapeutic effect of point-injection of compound Methylthioninum Chloride is significantly better than that of acupuncture therapy in the treatment of PHN patients.