督脉铺灸治疗变应性鼻炎及对免疫功能的影响

目的:观察督脉铺灸治疗变应性鼻炎的疗效及对免疫功能的影响。方法:将66例变应性鼻炎患者按随机数字表分为铺灸组34例和中药组32例。铺灸组采用督脉铺灸疗法,每周1次,每次30min,连续治疗2个月。中药组给予中成药玉屏风颗粒剂,每次5g,每日3次,连续治疗2个月。比较两组治疗后的临床疗效,酶联免疫法检测两组血浆白介素(IL)-2、IL-6、环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)含量,计算cAMP/cGMP比值。结果:铺灸组的总有效率为91.2%(31/34),明显高于药物组的81.3%(26/32,P0.05)。铺灸组及中药组血浆IL-2、IL-6、cGMP较治疗前均有所下降,cAMP较治疗前升高(P0.01),cAMP/cGMP比值升高;铺灸组IL-2、IL-6、cGMP下降较中药组更为明显(P0.01),cAMP上升更为显著(P0.01),cAMP/cGMP比值上升幅度更大(P0.01)。结论:铺灸疗法治疗变应性鼻炎有效,可能与其更有利于调动人体免疫系统功能有关。

Clinical Trial of Long-snake Moxibustion Treatment for Immune Function in Allergic Rhinitis Disease Patients

Objective To observe the curative effect of long-snake moxibustion in the treatment of allergic rhinitis.Methods A total of 66 patients with allergic rhinitis were randomized into moxibustion group(n=34)and control(herbal medicine)group(n=32)according to a computer-aided random digit table.Long-snake moxibustion stimulation over the Governor Vessel from Dazhui(GV 14)to Mingmen(GV 4)was performed for 30 min,once a week for 2consecutive months.Patients of the control group were treated by oral administration of"Yupingfeng"Granules(containing radix astragali,atrctylodis macrocephalae,etc.)one bag(5g)every time,3times a day for 2months.Plasma IL-2,IL-6,cAMP and cGMP contents were detected using ELISA.Results After the treatment,of the 32 and 34cases in the control and moxibustion groups,2and 6were cured,12 and 16experienced marked improvement in their symptoms(nasal mucosal edema,obstruction and discharging,sneezing),12 and 9were improved,6and 3invalid,with the effective rates being 81.3% and 91.2%,respectively.Results of ELISA showed that after the treatment,plasma IL-2,IL-6,and cGMP contents were significantly decreased in both the moxibustion and control groups(P<0.01),while plasma cAMP levels and cAMP/cGMP ratios were significantly up-regulated in both groups(P<0.01).The therapeutic effects of moxibustion were considerably superior to those of herbal medicine "Yupingfeng"in clinical effective rate and lowering plasma IL-2,IL-6,cGMP contents(P<0.01),and in raising plasma cGMP level and cAMP/cGMP ratio(P<0.01).Conclusion Long-snake moxibustion treatment is effective in improving symptoms of allergic rhinitis patients,which may be related to its function in mobilizing the body's immune function.