电针“四关”穴对慢性疲劳大鼠模型的行为学影响

目的 :观察复合应激致慢性疲劳大鼠模型行为学的变化以及电针“四关”穴的调整作用。方法 :大鼠随机分为四组 ,即正常对照组、模型组、电针四关穴组及电针它穴组。应用慢性束缚加冷水游泳的复合应激因素造模。采用旷场实验、鼠尾悬挂实验和力竭游泳实验观察大鼠行为学的变化 ,并从行为学角度对模型及针刺的防治作用进行评定。结果 :复合应激致慢性疲劳大鼠出现体力下降及抑郁样行为 ,电针“四关”穴可改善这种抑郁样表现 ,并能对抗体力的下降。结论 :电针四关穴能够明显防治应激所致的慢性疲劳 ,改善体力活动 ,对抗抑郁情绪

Effect of Electroacupuncture of Bilateral "Hegu"-"Taichong" on Behavior Changes of Chronic Fatigue Rats

Objective: To observe the effect of electroacupuncture (EA) of “Si guan" points bilateral “Hegu"(LI 4) and "Taichong" (LR 3)] on the behavior of chronic fatigue rats. Methods: 32 Wistar rats were evenly randomized into control group, model group, EA group 1 (“Si guan" points) and EA group 2 “Baihui"(GV 20) “Zusanli"(ST 36) “Taichong"(LR 3)]. Chronic fatigue model was established by forcing the rat to swim in cool water (30 min/time) and being trussed up (3 hr/time), continuously for 21 days. EA (4.5 V, 2～20 Hz) was applied to the aforementioned acupoints for 20 min, once daily and continuously for 21 days. The fatigue rats' behavior was tested by employing a specially made open box to record the rat's staying duration in the central check, check bestriding times, embellishing times and duration bottom leaving (above 1 cm) times and duration of the forelimbs], and by tail object suspending test (motionless duration and struggling times) and exhausted swimming duration. Results: In comparison with control group, the tail suspending motionless duration of model group increased significantly (P<0.05), and the struggling times and the exhausted swimming duration of model group decreased strikingly. After EA treatment, compared with model group, the check bestriding times, struggling times and the exhausted swimming duration of EA group 1 and the exhausted swimming duration of EA group 2 increased considerably (P<0.01); while the tail suspending motionless duration of both EA group 1 and group 2 reduced markedly (P<0.01). Conclusion: EA of bilateral “Hegu" “Taichong" can relieve and prevent chronic fatigue, improve physical performance and resist mental depression, and the effect of “Si guan" is slightly better than that of EA of “Baihui" “Zusanli" “Taichong".