隔物灸对寒湿凝滞型原发性痛经患者内皮素和一氧化氮含量的影响

目的:探讨隔物灸治疗寒湿凝滞型原发性痛经的作用机制。方法:以神阙穴艾炷隔盐姜灸、关元穴艾炷隔姜灸治疗寒湿凝滞型原发性痛经患者105例,并设中药月月舒冲剂对照组(104例)。观察两组疗效,同时随机对部分患者(两组各40例)治疗前后及正常人经期血浆内皮素(ET-1)含量(用放射免疫法)、血清一氧化氮(NO)含量(用硝酸还原酶法)进行检测。结果:艾灸组疗效明显优于对照组(P<0.05)。艾灸组和对照组治疗后血浆ET-1含量均较治疗前明显下降(P<0.01,P<0.05);治疗后艾灸组ET-1含量明显低于对照组(P<0.01)。治疗后两组血清NO含量与治疗前比较均明显升高(P<0.01),并均恢复至正常组水平(P>0.05)。结论:隔物灸治疗原发性痛经具有较好疗效,其作用机制之一可能与调节ET-1与NO失衡有关。

Influence of Ginger-Partitioned Moxibustion on Serum NO and Plasma Endothelin-1 Contents in Patients with Primary Dysmenorrhea of Cold-damp Stagnation Type

Objective To explore the mechanism of ginger-partitioned moxibustion in the treatment of cold-damp stagnation type primary dysmenorrhea(PD)patients.Methods A total of 209 PD outpatients of cold-damp stagnation type from 3 hospitals were randomized into moxibustion group(n=105)who were treated with ginger-partitioned moxibustion,and control group(n=104)who were asked to take Yueyue Shu Granules(an effective patent drug for PD).Ginger-partitioned moxibustion was applied to Shenque(CV 8)and Guanyuan(CV 4)from the menstrual onset on for the first course and 3 days before the onset for the second and third course,continuously for 3 days.Before and after the treatment,plasma endothelin-1(ET-1)and serum nitric oxide(NO)contents in those patients(n=40/group)and normal women(n=20)experiencing menstrual period were determined by radioimmunoassay and nitrate reductase method.Results After the treatment,of the 105 and 104 cases in moxibustion and control groups,58 and 32 cured,37 and 33 markedly effective,5 and 24 effective,5 and 15 failed,with the effective rates being 95.24% and 85.58% respectively.The therapeutic effect of moxibustion group was significantly better than that of control group(P<0.05).Before treatment,in comparison with normal group,plasma ET-1 contents in both moxibustion and control groups were significantly higher(P<0.01),while serum NO contents in these two groups markedly lower(P<0.01).After the treatment,self-comparison of both moxibustion and control groups showed that plasma ET-1 decreased significantly and serum NO levels in increased considerably(P<0.05,P<0.01),and the therapeutic effect of moxibustion group was markedly superior than that of control group in lowering plasma ET-1(P<0.01).Conclusion Ginger-partitioned moxibustion is effective in relieving primary dysmenorrhea patients' abdominal pain,which may be closely associated with its actions in lowering plasma ET-1 level and raising serum NO contents.