双黄连注射剂致过敏性休克流行病学特点

目的:探讨双黄连注射剂引起过敏性休克的流行病学特点与诱发因素。方法:通过检索1978~2005年医药学期刊,收集双黄连注射剂致过敏性休克病案72例,应用文献计量学方法对病案的流行病学资料进行分析。结果:资料中,18~44岁的青年患者比例最高(46.48%);男性37例(52.11%),女性34例(47.89%);患者原发疾病中上呼吸道感染比例最高(68.75%);过敏性休克多发生在给药30 m in内(89.36%);7例患者抢救无效死亡,死亡率9.72%。结论:双黄连注射剂可引起较严重的甚至危及生命的过敏性休克,其发生机制涉及患者体质等多方面因素。

Epidemiological characteristic of anaphylactic shock caused by Shuanghuanglian Injection

AIM: To investigate the epidemiological characteristic and causative factors of anaphylactic shock caused by Shuanghuanglian Injection(Flos Lonicerae Japonicae,Radix Scutellariae,Fructus forsythiae). METHODS: Domestic medicine periodicals were searched between 1978 and 2005,and 72 cases with anaphylactic shock caused by Shuanghuanglian Injection were analysed by literature metrologic method. RESULTS: There were large proportion of young sufferers from age 18 to 44 in the case reports,and male 52.11%,female 47.89%,the primary affections were mainly upper respiratory tract infection,the occurrence of ADRs was commonly within 30 mins after injection,seven patients died of the terrible anaphylactic shock. CONCLUSION: Shuanghuanglian Injection may induce dangerous,even fatal anaphylactic shock,its mechanism includes many factors,such as patient's physical constitution.