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| 毒性中药生川乌质量标准研究 | |
| 引用本文： | 王兆基,关锡耀,徐树棋,丁大伦,粟晓黎,林瑞超,郑秀云,冯国培.毒性中药生川乌质量标准研究[J].中成药,2006,28(5):651-655. |
| 作者姓名： | 王兆基 关锡耀 徐树棋 丁大伦 粟晓黎 林瑞超 郑秀云 冯国培 |
| 作者单位： | 1. 香港特别行政区政府化验所 2. 中国药品生物制品检定所,北京,100051 3. 香港中文大学 |
| 摘 要： | 目的:建立毒性中药生川乌的液质联用等质量检验方法。方法:采用显微、化学、液相色谱、液质联用方法进行定性鉴别、含量测定。结果:采用液相色谱质谱/质谱联用具有灵敏、专属性强等优点,适用于微量乌头生物碱的检测。结论:建立的方法可为其质量标准的提高提供参考。 |
| 关 键 词： | 生川乌 液质联用 毒性 |
| 文章编号： | 1001-1528（2006）05-0651-04 |
| 收稿时间： | 2005-10-15 |
| 修稿时间： | 2005-10-15 |
Quality standard for Radix Aconiti |
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| WONG Siu-kay,KWAN Sik-yiu,TSUI Shu-ki,TING Tai-lun,SU Xiao-li,LIN Rui-chao,CHENG Sau-wan,FUNG Kwok-pui.Quality standard for Radix Aconiti[J].Chinese Traditional Patent Medicine,2006,28(5):651-655. | |
| Authors: | WONG Siu-kay KWAN Sik-yiu TSUI Shu-ki TING Tai-lun SU Xiao-li LIN Rui-chao CHENG Sau-wan FUNG Kwok-pui |
| Institution: | 1. Government Laboratory, HKSAR ; 2. National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050; 3. The Chinese University of Hong Kong |
| Abstract: | AIM: Radix Aconite is unprocessed parent root tuber of Aconitum carmichaeli Debx.containing toxic diterpenoid alkaloids such as mesaconitine,aconitine and hypaconitine.To establish the quality standard for this potent herb. METHODS: The microscopic examination technique,HPLC-UV and LC-MS-MS methods had been used. RESULTS: These methods can be used to analyse the quality of this potent herb. CONCLUSION: This paper proposes microscopic examination technique and physio-chemical methods such as HPLC-UV and LC-MS-MS for the identification and quantitative analysis of the herbs. |
| Keywords: | Aconitum carmichaeli Debx diterpenoid alkaloids HPLC LC-MS-MS |
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