黄芩总黄酮纳米混悬剂冻干粉的表征及辅料对其粉体学性质和吸湿性的影响

目的制备黄芩总黄酮纳米混悬剂冻干粉后进行表征,并考察滑石粉、糊精、可溶性淀粉、羧甲基淀粉钠、微晶纤维素对其粉体学性质和吸湿性的影响。方法冷冻干燥法制备冻干粉后,差示扫描量热(DSC)、X射线衍射(XRD)、傅里叶红外光谱(FT-IR)进行结构表征。然后,考察5种辅料对粉体学参数(休止角、堆密度、振实密度)、溶出度、湿度参数(吸湿加速度、平衡吸湿率)的影响。结果药物与载体之间无相互作用,并且前者以无定型状态存在。滑石粉和糊精增加了冻干粉流动性,阻湿效果良好。结论不同辅料对黄芩总黄酮纳米混悬剂冻干粉的粉体学性质和吸湿性有明显影响。

Characterization of nanosuspension lyophilized powder of Scutellariae baicalensis total flavonoids and effects of excipients on the powder properties and hygroscopicity

AIM To prepare and characterize the nanosuspension lyophilized powder of Scutellariae baicalensis total flavonoids, and to investigate the effects of talcum powder,dextrin,soluble starch,sodium carboxymethyl starch,microcrystalline cellulose on powder properties and hygroscopicity.METHODS For the lyophilized powder prepared by freeze-drying method,differential thermal analysis(DSC),X-ray diffraction(XRD)and infrared spectroscopy(FT-IR)were used for structural characterization. Subsequently,the effects of five excipients on powder parameters(repose angle,bulk density,tap density),dissolution rate and humidity parameters(moisture absorption accelerated speed,equilibrium moisture absorption rate)were investigated.RESULTS No interaction between drug and carrier was found, and the former existed in an amorphous state. Both talcum powder and dextrin increased the fluidity of lyophilized powder and thus brought forth a good moisture-resistance effect.CONCLUSION Different excipients obviously affect the properties and hygroscopicity of nanosuspension lyophilized powder of Scutellariae baicalensis total flavonoids.