| 复方丹参滴丸防治大鼠早期糖尿病肾脏损害的研究 |
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| 引用本文： | 李佑生,王文健,马宇滢,刘毅,何春燕,何燕铭,陈伟华,应健.复方丹参滴丸防治大鼠早期糖尿病肾脏损害的研究[J].中成药,2007,29(1):40-44. |
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| 作者姓名： | 李佑生 王文健 马宇滢 刘毅 何春燕 何燕铭 陈伟华 应健 |
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| 作者单位： | 复旦大学附属华山医院中医科复旦大学中西医结合研究所,上海,200040 |
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| 摘 要： | 目的:考察复方丹参滴丸对大鼠早期糖尿病肾脏损害的疗效。方法:采用高糖高脂喂饲加低剂量STZ建立大鼠2型糖尿病肾病模型,给予复方丹参滴丸治疗12周,动态观察血糖及尿微量白蛋白尿等指标。结果:复方丹参滴丸大剂量时可降低血糖、减少尿微量白蛋白、减轻肾脏肥大、减少尿量,而中低剂量可降低血清甘油三酯水平,疗效优于氯沙坦。结论:复方丹参滴丸大剂量时有改善实验性大鼠2型糖尿病肾脏病变,主要是改善微量白蛋白尿的作用。
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| 关 键 词： | 复方丹参滴丸 糖尿病肾病 微量白蛋白尿 胰岛素抵抗 大鼠 |
| 文章编号： | 1001-1528（2007）01-0040-04 |
| 修稿时间： | 2006-06-18 |
Effect of Compound Danshen Drop Pills on early stage diabetic nephropathy in rat models |
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| LI You-sheng,WANG Wen-Jian,MA Yu-ying,LIU Yi,HE Chun-yan,HE Yan-ming,CHEN Wei-hua,YING Jian.Effect of Compound Danshen Drop Pills on early stage diabetic nephropathy in rat models[J].Chinese Traditional Patent Medicine,2007,29(1):40-44. |
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| Authors: | LI You-sheng WANG Wen-Jian MA Yu-ying LIU Yi HE Chun-yan HE Yan-ming CHEN Wei-hua YING Jian |
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| Institution: | Dept. of TCM, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China |
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| Abstract: | AIM: To explore the effect of Compound Danshen Drop Pills(CDDP) on early stage of diabetic nephropathy in rat models. METHODS: Diabetic nephropathy of type 2 diabetes rat model was established by feeding with high glucose high fat diet with low dose STZ injection.Rats were treated with CDDP then and blood glucose,urinary micro-albumin and other targets were measured at different time points. RESULTS: High dose of CDDP decreased blood glucose level,reduced urinary micro-albumin, glomerular hypertrophy and urinary volume.Middle and low dose of CDDP decreased blood triglyceride level.These effects were better than Losartan. CONCLUSION: High dose of CDDP could ameliorate diabetic nephropathy in type 2 diabetes rat models,and the main effect was reducing urinary micro-albuimn. |
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| Keywords: | Compound Danshen Drop Pills diabetic nephropathy microalbuminuria insulin resistance rat |
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