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复方丹参胶囊对离体大鼠心脏缺血再灌注损伤的保护作用
引用本文:张春芳,李锐.复方丹参胶囊对离体大鼠心脏缺血再灌注损伤的保护作用[J].中成药,1993,15(12):30-31.
作者姓名:张春芳  李锐
作者单位:济宁医学院,苏州中药研究所,苏州中药研究所,苏州中药研究所,苏州中药研究所,苏州中药研究所 272113
摘    要:采用离体大鼠Langendorff心脏缺血再灌注模型,观察复方丹参胶囊对心肌缺血再灌注损伤的保护作用。实验结果显示,本品能降低缺血再灌后室颤发生率;促进再灌后冠脉流量的恢复;防止再灌后心肌收缩力和左室内压的下降;能降低心肌再灌后乳酸脱氢酶(LDH)和丙二醛(MDA)的生成量,增加心肌再灌后超氧化物歧化酶(SOD)的活性。结果提示:本品对心肌缺血再灌注损伤的保护作用可能与其清除氧自由基和抑制脂质过氧

关 键 词:复方丹参胶囊  心肌缺血  再灌注损伤

Protection Action of Compound Danshen Capsules (Radix Salviae Miltiorrhizae,Radix Astragali seu Hedysari,etc.) on Reperfusion-lnjury of Blood-Depleting Heart off Rat Body
Zhang Chunfen,Li Rui,et al..Protection Action of Compound Danshen Capsules (Radix Salviae Miltiorrhizae,Radix Astragali seu Hedysari,etc.) on Reperfusion-lnjury of Blood-Depleting Heart off Rat Body[J].Chinese Traditional Patent Medicine,1993,15(12):30-31.
Authors:Zhang Chunfen  Li Rui  
Abstract:A model of reperfusion of blood-depleting heart off rat body was used in the investigation of the protection actions of Compound Danshen Capsules on reperfusion-injury of blood depleting heart. The result indicated that it lower the incidence rate of ventricle twitch,promote the restoration of coronary bleed flow, prevent decreasing in contractility of cardiac muscle and in internal pressure of left ventricle,lower the prodution level of lactic dehydrogenase(LDH) and malonaldehyde(MDA),increase the activity of superoxide dismutase(SOD) after blood-depletion and reperfusion. It was suggested that its protection actions be ascribed to its clearance function on oxygen free-radical and inhibition on peroxidation of lipid.
Keywords:Compound Danshen Capsules  reperfusion-injury of blood-depleting heart  oxygen free-radical  
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