心脑通胶囊对实验性脑缺血的保护作用

目的：研究心脑通过实验性脑缺血的保护作用。方法：使用小白鼠断头模型以及结扎双侧颈总动脉模型，观察断头后张口喘气时间和小鼠存活时间，利用结扎大鼠双侧颈总动脉形成急性实验性不完全性脑缺血模型，观察心脑通过脑水量、毛细血管通透性及脑组织中过化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）含量等方面的影响；用栓线法建立大脑中动脉阻塞（ＭＣＡＯ）模型，观察心脑通过大鼠血浆中组织纤溶酶原激活物（ｔ－ＰＡ）的组织纤溶酶原

Protection of Xinnaotong Capsules on Experimental Cerebral Ischemia

Objective: To study the protection of Xinnaotong Capsules on experimental cerebral ischemia. Methods: Observing the gasp time and survival time of mice after decapitation on mouse decapitation model and the model of ligation of bilateral common carotid artery; observing the influence of Xinnaotong Capsules on the water content of brain, capillary permeability, SOD and MDA levels in brain tissue on the acute experimental imcomplete cerebral ischemia model induced by the ligation of bilateral common carotid artery of rat; and observing the influence of Xinnaotong Capsules on activities of t PA and PAI in rat blood, and pathology and nerve symptom on MCAO model. Results: Xinnaotong Capsules can obviously prolong the gasp time and survival time of mice; decrease the water content of brain, capillary permeability, MDA production and SOD activity; raise t PA activity of blood, abate brain tissue injury and improve behavior disorder. Conclusion: Xinnaotong Capsules possesses stronger protection, which has relation to anti free radical and activated fibrinolytic system.