| 乳香-没药配伍前后汤液理化参数变化与化学成分的关联分析 |
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| 引用本文： | 陈婷,宿树兰,钱叶飞,尚尔鑫,朱华旭,段金廒.乳香-没药配伍前后汤液理化参数变化与化学成分的关联分析[J].中成药,2012,34(8):1529-1536. |
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| 作者姓名： | 陈婷 宿树兰 钱叶飞 尚尔鑫 朱华旭 段金廒 |
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| 作者单位： | 1. 南京中医药大学江苏省方剂高技术研究重点实验室,江苏南京210046;江苏大学药学院江苏镇江212013
2. 南京中医药大学江苏省方剂高技术研究重点实验室,江苏南京,210046 |
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| 基金项目： | 国家自然科学基金资助项目(30973885);江苏省高校自然基金重大基础研究资助项目(11KJA36002,06KJA36022);国家科技支撑计划(2008BA151B01);江苏省方剂高技术研究重点实验室建设项目资助(BM2010576);江苏省理血方剂创新药物工程中心建设项目资助(2009) |
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| 摘 要： | 目的 探讨乳香-没药水提液(汤液)理化性质与化学成分变化之间的关系.方法 测定汤液的理化参数(电导率、盐度、浊度、黏度、pH值)；采用UPLC-MS/MS分析汤液中的化学成分组成；采用逐步回归分析方法对汤液的理化参数与化学成分的柏关性进行分析,并进行验证试验.结果 汤液中的化学成分组成及其含有量变化影响着汤液的浊度、黏度等理化参数；其中五环三萜酸酯类化合物与汤液的浊度呈显著正相关,倍半萜类化合物与汤液的黏度呈显著负相关.结论 为深入研究乳香-没药配伍协同增效的物质基础提供了一定的依据.
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| 关 键 词： | 乳香 没药 药对 物理化学参数 化学成分 关联分析 |
Association analysis between the physiochemical parameters and the chemical constituents in Olibanum and Myrrha decoction before and after combination |
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| CHEN Ting
,
SU Shu-lan
,
QIAN Ye-fei
,
SHANG Er-xin
,
ZHU Hua-xu
,
DUAN Jin-ao.Association analysis between the physiochemical parameters and the chemical constituents in Olibanum and Myrrha decoction before and after combination[J].Chinese Traditional Patent Medicine,2012,34(8):1529-1536. |
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| Authors: | CHEN Ting SU Shu-lan QIAN Ye-fei SHANG Er-xin ZHU Hua-xu DUAN Jin-ao |
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| Institution: | 1 (1.Jiangsu Key Laboratory for Traditional Chinese Medicine Formulae Research,Nanjing University of Chinese Medicine,Nanjing 210046,China;2.Jiangsu University,Zhenjiang 212013,China) |
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| Abstract: | AIM To explore the correlation between the physiochemical parameters and the chemical components in Olibanum and Myrrha decoction before and after combination.METHODS Determination of the electrical conductivity,salinity,turbidity,viscosity,pH value of Olibanum and Myrrha decoction was performed.UPLC-MS/MS was used to measure the chemical components of the decoction.The step by step regression method was adopted to evaluate the correlation between physiochemical parameters and chemical components.RESULTS The change of turbidity and viscosity in the decoction could reflect the changes of the chemical compositions.And the pentacyclic triterpenoid ester compounds in the decoction were significantly positive correlation with the turbidity,the sesquiterpene compounds were significantly negative correlation with viscosity.CONCLUSION The research may provide a foundation for synergies of Olibanum and Myrrha. |
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| Keywords: | Olibanum Myrrha herbal pair physiochemical parameters chemical components association analysis |
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