| 桑椹乙酸乙酯萃取物对链脲佐菌素致高血糖大鼠的降血糖作用 |
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| 引用本文： | 王瑞坡,王珂,李姣,赵迪,王洁琼,瞿伟菁.桑椹乙酸乙酯萃取物对链脲佐菌素致高血糖大鼠的降血糖作用[J].中成药,2011,33(10):1668-1672. |
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| 作者姓名： | 王瑞坡 王珂 李姣 赵迪 王洁琼 瞿伟菁 |
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| 作者单位： | 华东师范大学生命科学学院,上海,200062 |
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| 基金项目： | 上海市经委重点项目(07XI2-029) |
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| 摘 要： | 目的 研究桑椹乙酸乙酯萃取物(EEM)对链脲佐菌素(STZ)诱导的糖尿病大鼠的降糖作用.方法 用STZ诱导出1型糖尿病大鼠模型分成5组,分别用水、格列苯脲和0.1、0.2、0.3g/kg EEM连续灌胃3周,每周测定血糖.结果 与模型对照组相比,0.2 g/kg EEM能显著降低糖尿病大鼠血糖、糖化血清蛋白,刺激胰岛素分泌,增加体质量,调节血脂,增强机体抗氧化能力,同时具有一定的保护肾脏的功能,但对肝脏有一定副作用.结论 EEM能有效的控制糖尿病大鼠血糖水平,一定程度改善糖脂代谢紊乱.
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| 关 键 词： | 桑椹萃取物 糖尿病 糖化血清蛋白 链脲佐菌素(STZ) |
Antihyperglycemic effect of ethyl acetate extract of mulberry fruit on diabetic rats induced by streptozotocin |
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| WANG Rui-po
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WANG Ke
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LI Jiao
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ZHAO Di
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WANG Jie-qiong
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QU Wei-jing.Antihyperglycemic effect of ethyl acetate extract of mulberry fruit on diabetic rats induced by streptozotocin[J].Chinese Traditional Patent Medicine,2011,33(10):1668-1672. |
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| Authors: | WANG Rui-po WANG Ke LI Jiao ZHAO Di WANG Jie-qiong QU Wei-jing |
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| Institution: | WANG Rui-po,WANG Ke,LI Jiao,ZHAO Di,WANG Jie-qiong,QU Wei-jing*(School of Life Science,East China Normal University,Shanghai 200062,China) |
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| Abstract: | AIM To study the antihyperglycemic effect of ethyl acetate extract of mulberry(EEM) fruit on diabetic rats induced by streptozotocin(STZ).METHODS The type 1 diabetic rats induced by STZ were randomly divided into 5 groups,and given intragastrically water,glibenclamide and three different levels(0.1 g/kg,0.2 g/kg,and 0.3 g/kg) of EEM,respectively once a day for 3 weeks,and the glucose level was determined per week.RESULTS As compared with control group,the middle-dosage EEM could significantly reduce the lev... |
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| Keywords: | extract of mulberry diabetes glycosylated serum protein streptozotocin(STZ) |
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