Cerb—B-2、P53和nm23在乳腺癌组织中表达相关性及意义

目的：探讨Cerb—B-2、P53和nm23基因在乳腺癌中的表达与转移及预后的关系。方法：采用免疫组织化学（SP法）对乳腺癌Cerb-B-2、P53和nm23的表达进行检测。结果：Cerb—B-2阳性率为68．4％，P53为51．8％，nm23为71．1％。Cerb-B-2和P53与肿瘤临床分期和淋巴结转移呈正相关，差异有统计学意义，与患者年龄无显著相关性。nm23基因蛋白的表达与临床分级、淋巴结转移呈负相关，差异有统计学意义，而与患者年龄无显著相关性。结论：Cerb—B-2、P53和nm23基因参与乳腺癌的发生发展过程；联合检测对预测乳腺癌淋巴结转移及判断预后有重要意义。

Relevance and significance of expression of Cerb-B-2, P53 and nm23 on breast Cancer

Objective： To investigate the expression of oncogenes Cerb-B-2, P53and nm23, and the relationship of the genes with metastasis and prognosis in patients with primary breast carcinoma. Methods： The expression of Cerb-B-2, P53and nm23 was detected by immunohistochemical （s-p methods） in 114 cases of breast carcinoma. Results： The positive expression of Cerb-B-2, P53, and nm23were 68.4%, 51.8% and 71.1%. The expression of Cerb-B-2, P53 were positively correlated with TNM stage and lymph node metastasis （P〈0.01）, but did not relate to age; nm23 was negatively correlated with TNM stage and lymph node metastasis, and did not relate to age. Conclusion： Oncogenes Cerb-B-2, P53 and nm23 may play an important role in the development and progression of beast carcinoma. The combined detection of Cerb-B-2, P53 and nm23 geneproteins has positive effects on predicting the lymph node metastasis and the prognosis of breast carcinoma.