雷贝拉唑联合莫沙必利治疗胃食管反流病临床疗效观察

目的:观察雷贝拉唑联合莫沙必利治疗胃食管反流病的疗效。方法:将75例胃食管反流病患者随机分为治疗组和对照组,其中治疗组37例,对照组38例;对照组给予奥美拉唑钠肠溶片联合多潘立酮片治疗,治疗组给予雷贝拉唑钠肠溶胶囊联合枸橼酸莫沙必利片治疗,两组均连续用药8周,观察两组患者治疗前后临床症状改善情况、GERD症状评分及胃镜。结果:治疗组临床症状改善优于对照组,差异有显著性意义(P0.05);治疗组EE患者胃镜疗效优于对照组,差异有显著性意义(P0.05)。结论:雷贝拉唑联合莫沙必利治胃食管反流病有较高的治愈率和症状改善率,临床疗效优于奥美拉唑联合多潘立酮治疗。

Clinical observation on treating GERD by rabeprazole plus mosapride

Objective：To observe the clinical effects of rabeprazole plus mosapride on treating gastroesophageal reflux disease.Methods：75 patients were randomly divided into the treatment group（37 cases） and the control group（38 cases）,The control group was given omeprazole sodium enteric-coated tablets plus domperidone therapy,the treatment group were treated with rabeprazole sodium enteric-coated capsules plus mosapride citrate tablets,both groups for treatment of 8 weeks,improvement of clinical symptoms,GERD symptom score and gastroscopy in the two groups were observed before and after the treatment.Results：Improvement of clinical symptoms of the treatment group was better than that of the control group,the difference was statistically significant（P0.05）;Efficacy of gastroscopy in the EE patients of the treatment group was better than that of the control group,there were significant differences（P0.05）.Conclusion：Rabeprazole plus mosapride had a higher cure rate and symptom improvement rates in treating gastroesophageal reflux disease,the clinical efficacy was superior to omeprazole domperidone.