川芎嗪对心肺复苏后脑缺血再灌注损伤的临床研究

目的：探讨川芎嗪用于治疗心肺复苏后脑缺血再灌注损伤患者的，法床效果。方法：选取院内心脏骤停心肺复苏成功后脑缺血再灌注损伤患者50例，随机分为对照组和观察组。在心肺复苏成功，患者的自主循环恢复后，观察组患者给予川芎嗪葡萄糖静脉滴注，对照组患者给予葡萄糖注射液静滴。检测两组患者治疗前及治疗后10d的SOD、MDA、NO水平，并综合评价，陆床疗效。结果：观察组患者的血中SOD、MDA、NO及总有效率较对照组均有明显优势，差异有统计学意义（P〈0．05）。结论：在心肺复苏成功自主循环恢复后即对患者采用川芎嗪静滴治疗，可以提高心肺复苏后脑缺血再灌注损伤患者的预后质量。

Clinical research on treating cardiopulmonary resuscitation cerebral ischemia-reperfusion injury with TMP

Objective： To explore the clinical effect of treating cardiopulmonary resuscitation cerebral ischemia-reperfusion injury with TMP. Methods： Selected 50 cases of patients with cardiopulmonary resuscitation of cardiac arrest cerebral ischemia-reperfusion injury in our hospital, then randomly divided them into control group and observation group. After the success of cardiopulmonary resuscitation and restoration of spontaneous circulation in patients, observation group applying TMP intravenous infusion of glucose, and control group applying intravenous infusion of glucose, then detected their level of SOD, MDA and NO in 10 days before and after the treatment, and comprehensively evaluate their clinical effects. Results： The blood of patients with SOD, MDA, NO and total efficiency rate had obviously advantages than control group, which difference was statistically significant （P〈0.05）. Conclusion： It could improve the quality of cardiopulmonary resuscitation cerebral iscbemia-reperfusion injury that applying TMP intravenous treatment to patients after restoration of cardiopulmonary resuscitation spontaneous circulation.