红曲治疗颈动脉粥样硬化斑块的临床疗效观察

目的：探讨红曲治疗颈动脉粥样硬化斑块的临床疗效。方法：60例经彩色多普勒超声检测证实有不同程度颈动脉粥样硬化斑块形成的患者,采用随机数字表法分为红曲治疗组和洛伐他汀治疗组各20例,另外20例患者作为空白对照组。红曲组予红曲治疗,6g/次,2次/d,饭后予开水150ml泡20min,红曲完全溶解后服用,连服6个月;洛伐他汀组予洛伐他汀胶囊20mg口服,1次/d,也连服6个月;对照组不予相关药物干预。观察用药6个月后中医证侯疗效及彩色多普勒超声检测颈动脉内膜-中膜厚度（IMT）和Crouse斑块积分的变化。结果：两治疗组治疗6个月后中医证侯明显改善,两治疗组组间比较无统计学意义;而空白对照组治疗前后中医证侯无变化甚至加重,与两治疗组比较有统计学意义。两治疗组治疗后IMT和Crouse斑块积分的均显著改善,两组间比较无统计学意义;而空白对照组治疗前后无变化甚至加重。结论：红曲与洛伐他汀均具有改善颈动脉粥样硬化患者临床症状及减轻和消退颈动脉粥样硬化的作用,且红曲副作用少,安全性大,值得临床应用。

Clinical effect observation on treating carotid atherosclerosis plaque with red rice

Objective： To investigate the clinical effect on treating carotid atherosclerosis plaque with red rice. Methods： 60 case of different degrees of carotid atherosclerotic plaque, randomly divided into red rice treated group and lovastatin treated group each of 20 cases, in the other 20 patients as control group. Red rice treated group was gave the rad rice, 6g/time, 2 time/d, 150ml to boiling water soak 20 minutes after a meal, to take after tad rice is completely dissolved, and even served 6 months; The control group did not related to medicine intervention. Observation TCM syndrome curative effect after 6 months and Color Doppler ultrasound detection of carotid intima-media thickness （IMT） and Crouse plaque integral. Results： The TCM syndrome significantly was improved after 6 months; there is no statistical significance between the two groups; before and after treatment the TCM syndrome without change of the control group, there was statistical significance compared with two in the treated group. Conclusion： Monascus and lovastatin has improved the clinical symptoms in patients with carotid atherosclerosis and reduce and regression of carotid atherosclerosis, Monascus has less side effect, high safety, and is worthy of clinical application.