超滤法有效提取分离丹参水溶性成分的工艺研究

目的：尽量除去杂质同时保留丹参水溶性酚酸；方法：采用超滤法，滤膜的截留分子量（molecular weight cut off, MWCO）为200，进行提取分离；采用正交试验确定较佳超滤工艺；并对超滤过程中加水方式进行优化；结果：考察各因素对丹参水溶性酚酸和杂质含量比参数T和丹参水溶性酚酸透过收率的影响显著程度，得到较佳分子截留工艺组合：料液初始浓度2.2 g/L、温度40℃，操作压力1.0 MPa；优化超滤过程加水方式使T和丹参水溶性酚酸透过收率分别提高至14.76和12.65%；结论：该法能有效除去杂质而提高丹参水溶性酚酸的相对含量。

Study On Effective Extraction and Separation of Water-Soluble Components from Salvia Miltiorrhiza Bge by ultrafiltration

Objective：To remove the impurities and retained watersoluble phenolic acids from Salvia Miltiorrhiza Bge.Methods：Using ultrafiltration membrane MWCO （molecular weight cut off, MWCO） of 200, extraction and separation;The preferred ultrafiltration is determined by orthogonal experiment; And the way of adding water is optimized in ultrafiltration process. Result：The effect of various factors on T and the ratio of water-soluble phenolic acids filtered through the membrane were studied; The optimum conditions of molecular intercept were as follows：Initial concentration of materials liquid is 2.2 g/L, temperature is 40℃and operating pressure is 1.0 Mpa;T and the ratio of watersoluble phenolic acids filtered through the membrane increase to 14.76 and 12.65%respectively by the way of adding water test which is optimized in ultrafiltration process. Conclusion：The method can effectively remove impurities and improve the content of watersoluble phenolic acids from Salvia Miltiorrhiza Bge.