黄连解毒汤对幼龄自发性高血压大鼠炎性因子、血管性假血友病因子水平的影响

目的研究黄连解毒汤对幼龄自发性高血压大鼠(SHR)炎性因子、假性血管性血友病因子、血压等的影响,探讨黄连解毒汤预防高血压的机制。方法雄性6周幼龄自发性高血压大鼠16只随机分为黄连解毒汤组、模型组2组,治疗6周,检测治疗前后的血压变化,测定大鼠血浆高敏C反应蛋白(hs-CRP)、单核细胞趋化蛋白1(CMP-1)及血管性假血友病因子(vWF)浓度变化,并以同龄Wistar Kyoto大鼠8只做空白对照比较。结果SHR血压呈进行性增高,血浆中hs-CRP、vWF升高,CMP-1无显著变化。黄连解毒汤可以控制幼龄SHR血压,降低SHR血浆hs-CRP、vWF含量。结论早期应用黄连解毒汤可以改善SHR的炎性反应和保护血管内皮。

Effects of Huanglianjiedu-Decoction on inflammatory factors,von-willebrand factors of young age SHR

Objective Research the variety of the inflammatory factors, von-willebrand factors and blood pressure of young age SHR with Huanglianjiedu-Decoction, and discuss the mechanism to prevent hypertension. Method 16 6-week-age male SHR were divided into two groups-Huanglianjiedu-Decoction group and the model group-in random, treated for 6 weeks, tested the changes of the blood pressure pre and post the treatment separately, measured the density changes of the hs：CRP, MCP-1 and vWF by ELLSA for those rats, and compared with 8 WKY rats in the same age for blank control. Result The blood pressure of young age SHR increased progressively. The hs-CRP and vWF increased, and MCP-1 did not change significantly in the SHRs＇ plasma. Huanglian Jiedu decoction could control the blood pressure of the young SHR and decreased the content of the hs-CRP and vWF. Conclusion Using Huanglian Jiedu decoction in the early period could improve the inflammatory response and protect the vascular endothelial in the SHR