消瘤丸对子宫内膜异位症大鼠异位病灶的影响

目的:观察消瘤丸对子宫内膜异位症大鼠异位病灶的作用,研究其对异位子宫内膜雌激素受体(ER)的影响。方法:SD雌性大鼠100只,采用手术诱导法建立子宫内膜异位症大鼠模型,成模大鼠随机分成模型组、桂枝茯苓丸阳性对照组、消瘤丸低、中、高剂量组。各组大鼠灌胃给药8周,模型组大鼠给予生理盐水;治疗结束后,观察各组大鼠异位内膜的面积变化及对异位子宫内膜ER的影响。结果:消瘤丸低、中、高剂量组大鼠异位子宫内膜生长活动受抑制,异位子宫内膜面积较治疗前显著缩小(P<0.01);消瘤丸低、中、高剂量组治疗后异位子宫内膜面积无显著性差异(P>0.05);消瘤丸低、中、高剂量组对大鼠异位子宫内膜ER的影响无统计学差异(P>0.05),说明药物没有通过ER表达。结论:消瘤丸对子宫内膜异位症大鼠有显著的治疗作用,其对异位子宫内膜的抑制作用与异位内膜局部总的ER可能无直接关系。

Xiaoliuwan pill for endometriosis, ectopic endometrium of rats

Objective： To observe Xiaoliuwan pill for endometriosis,the role of ectopic lesions in rats,study of ectopic endometrial estrogen receptor（ER） effect.Methods SD female rats were 100,was established by the use of surgery-induced rat model of endometriosis,into the model rats were randomly divided into model group,the positive control group GFW,Xiaoliuwan pill low,medium and high dose group.The rats gavage for 8 weeks,rats given saline;the end of treatment,ectopic endometrium of rats the size of ectopic endometrial changes and the impact of ER.The results Xiaoliuwan pill low,medium and high dose group activities ectopic endometrial growth was inhibited,ectopic endometrial area was significantly reduced compared with before treatment（P 0.01）;Xiaoliuwan pill low,medium and high dose group treatment of ectopic endometrial area was no significant difference（P 0.05）;Xiaoliuwan pill low,medium and high dose group of rats the effects of ectopic endometrial ER was no significant difference（P 0.05）,shows drugs did not pass the ER expression.Conclusion Xiaoliuwan pill for endometriosis treatment of rats with a significant role in the inhibition of ectopic endometrium and ectopic endometrium of the total local ER may have no direct relationship.