耳针对血管性痴呆大鼠行为学及大脑皮质STAT1表达的影响 |
| |
引用本文: | 卢雨微,付宗英.耳针对血管性痴呆大鼠行为学及大脑皮质STAT1表达的影响[J].内蒙古中医药,2014(1):100-101. |
| |
作者姓名: | 卢雨微 付宗英 |
| |
作者单位: | 贵阳医学院附属医院针灸科 |
| |
摘 要: | 目的:探讨耳穴改善血管性痴呆(VascularDementia,VD)大鼠学习记忆障碍的反应机制。方法:雄性Wistar大鼠30只,随机分为3组:正常组,模型组,耳针组,采用4-血管阻断(4-Vesselocclusion,4-VO)全脑缺血再灌注制备VD大鼠模型,Y-型迷宫检测各组大鼠学习记忆能力,SABC法检测大脑信号转导和转录激活子1(STAT1)阳性细胞的表达。结果:耳针能显著降低模型鼠大脑皮质的信号转导和转录激活子1(STAT1)免疫阳性细胞数,升高其平均光密度值(P0.05)。结论:耳针能减少或抑制STAT1的过度产生,改善VD模型大鼠学习记忆。
|
关 键 词: | 血管性痴呆 耳针 行为学 信号转导和转录激活子1(STAT1) |
The relationship between auricular acupuncture and behavioral test and expression of STAT1 of cerebral cortex in vascular dementia rat |
| |
Institution: | LU Yu-wei;Department of Acupuncture, Affiliated Hospital of Guiyang Medical College; |
| |
Abstract: | Objective: To study the mechanism of auricular acupuncture for improvement of learning and memory disorders in the rat of vascular dementia (VD) . Methods: Male wistar 30 rats were randomly divided into three groups: normal control group, model group,ear acupuncture group,the vascular dementia model of rat was performed by 4-vesselocclusion method, learning and memory abilities of rats in 3 groups were evaluated with Y-type were test. Immunohistochemical method was used to detect the expression of STAT1. Results: Auricular needling could lower significantly the STAT1 immunoreaetive neurons and higher its average light density in cerebral cortex in model rat (P〈0.05).Conclusion: Auricular needling could reduce or inhibit the over-production STAT1 in brain, improving the learning and memory capacity of VD model rats. |
| |
Keywords: | |
本文献已被 CNKI 维普 等数据库收录! |
|