| 肉豆蔻挥发油的药理毒理研究 |
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| 引用本文： | 韩蕾,马颖芳,袁子民,贾天柱,周晓辉.肉豆蔻挥发油的药理毒理研究[J].中华中医药学刊,2007,25(5):900-904. |
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| 作者姓名： | 韩蕾 马颖芳 袁子民 贾天柱 周晓辉 |
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| 作者单位： | 辽宁中医药大学药学院,辽宁,大连,116600 |
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| 摘 要： | Objective:The volatile oil of nutmeg was used to study the acute toxicity,central nervous system depressant activity and the action on acute myocardial infarction.Methods:Volatile oil was administrated orally.LD50 in mice of was investigated and calculated.Its potentiation effect on hypnosis induced by subthreshold pentobarbital sodium in mice was observed;its influence on latency and percentage of convulsion,death latency and percentage of survival induced by strychnine was also observed;moreover,its anti-acute myocardial infarction effect in rats was tested.Results:LD50 in mice was 7.67g /kg.At the dose of 1.07g /kg(p.o),the volatile oil produced potentiation effect on hypnosis induced by subthreshold dose of pentobarbital sodium in mice,prolonged death latency and increased the survival rate for strychnine-induced convulsion in mice.There were no remarkable effects on acute myocardial infarction.Conclusion:These observations indicated that the volatile oil of nutmeg had central depressant actions and no remarkable effect on acute myocardial infarction.
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| 关 键 词： | 急性毒性 中枢抑制 急性心肌梗死 挥发油 肉豆蔻 |
| 文章编号： | 1673-7717（2007）05-0900-05 |
| 收稿时间： | 2006-12-27 |
| 修稿时间： | 2006-12-27 |
Toxicological and Pharmacological Studies On the Volatile Oil from Nutmeg (Myristica Fragrans) |
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| HAN Lei,MA Ying-fang,YUAN Zi-min,JIA Tian-zhu,ZHOU Xiao-hui.Toxicological and Pharmacological Studies On the Volatile Oil from Nutmeg (Myristica Fragrans)[J].Chinese Archives of Traditional Chinese Medicine,2007,25(5):900-904. |
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| Authors: | HAN Lei MA Ying-fang YUAN Zi-min JIA Tian-zhu ZHOU Xiao-hui |
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| Abstract: | Objective:The volatile oil of nutmeg was used to study the acute toxicity,central nervous system depressant activity and the action on acute myocardial infarction.Methods:Volatile oil was administrated orally.LD50 in mice of was investigated and calculated.Its potentiation effect on hypnosis induced by subthreshold pentobarbital sodium in mice was observed;its influence on latency and percentage of convulsion,death latency and percentage of survival induced by strychnine was also observed;moreover,its anti-acute myocardial infarction effect in rats was tested.Results:LD50 in mice was 7.67g /kg.At the dose of 1.07g /kg(p.o),the volatile oil produced potentiation effect on hypnosis induced by subthreshold dose of pentobarbital sodium in mice,prolonged death latency and increased the survival rate for strychnine-induced convulsion in mice.There were no remarkable effects on acute myocardial infarction.Conclusion:These observations indicated that the volatile oil of nutmeg had central depressant actions and no remarkable effect on acute myocardial infarction. |
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| Keywords: | acute toxicity central depression acute myocardial infarction volatile oil nutmeg |
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