淫羊藿苷复合物与利多卡因凝胶治疗原发性早泄的临床对比研究

目的:对比分析淫羊藿苷复合物和利多卡因凝胶治疗原发性早泄的临床疗效。方法:将原发性早泄患者96例随机分为治疗组(淫羊藿苷复合物组)和对照组(利多卡因凝胶组)分别为48和48例,截止试验结束每组各有42例完成试验。每次治疗组用淫羊藿苷复合物和对照组用利多卡因凝胶在性生活前10～15min分别外涂于涂于阴茎头、系带、冠状沟部,涂擦形成一覆盖膜即可,无须过厚(具体用量视阴茎大小而定,一般每次1.5～2.0g),疗程为4周,期间控制性交次数3～8次,比较治疗前后阴道内射精时间(IELT)、CIPE-5评分、性生活满意度和IIEF-5评分变化和不良反应。结果:①治疗4周后发现,治疗组治疗后IELT值由(1.05±0.42)提高到(5.45±1.25),对照组治疗后IELT由(1.04±0.58)提高到(3.24±1.18),两组均能显著提高IELT,但治疗组优于对照组(P0.05);②治疗组治疗后CIPE-5评分由(11.2±2.4)提高到(24.4±2.1),对照组治疗后CIPE-5由(12.1±1.8)提高到(19.7±3.2),两组均能显著提高CIPE-5评分,但治疗组优于对照组(P0.05)③治疗组治疗后性生活满意度满意为61.90%,基本满意为26.19%,总满意度为88.09%;对照组治疗后性生活满意度满意为47.62%,基本满意为19.05%,总满意度为66.67%,治疗组优于对照组(P0.01);④治疗组治疗后IELT值由(1.05±0.42)提高到(5.45±1.25),对照组治疗后IELT由(1.04±0.58)提高到(3.24±1.18),两组均能显著提高IELT,但治疗组优于对照组(P0.05)。⑤对照组42例以及治疗组42例病人中理化检查均无异常。不良反应中对照组性交时快感下降3例,局部红斑1例,以上不适停药后均消失,不良反应发生率为9.52%,治疗组未见明显不适。结论:淫羊藿苷复合物治疗原发性早泄效满意,且具有使用方便,安全性较高的优势,并可能提高患者的勃起功能。

Clinical Comparative Study of Icariin Complex Versus Lidocaine for Treatment of Primary Premature Ejaculation

Objective:To compare the efficacy of Icariin Complex with lidocaine.Methods:Divide the primary premature ejaculation suffers into two groups like the therapy group(Icariin group)and the control group(lidocaine gelgroup)at random,and each group had 48,and 42 suffers in each group respectively had finished the experiment until the deadline of the experiment.Spread proper Icariin(in therapy group)and lidocaine(in the control group)respectively(the medicine quantity depends on the size of the penis)on the skin and the head of the penis in each night,and the course of treatment was 4 weeks.Compare the differences of IELT,CIPE-5 grade,sexual life satisfaction degree,and the changes of penis IIEF-5 before and after the treatment.Results:①At the end of a 4-week treatment,the treatment group IELT value improve from(1.05±0.42)to(5.45±1.25),and the control group IELT value from(10.4±0.58)increased to(32.4±1.18),both groups can significantly improve the IELT,but the treatment group was better than control group(P< 0.05).②In therapy group,CIPE-5 from(11.2 ± 2.4)increased to(24.4±2.1),the control group after treatment,CIPE-5 from(12.1±1.8)improved to(19.7±3.2),both groups can significantly improve the rate,but the therapy group wass superior to the control group(P < 0.05).③In the treatment group after treatment,satisfactory sexual satisfaction was 61.90%,basic satisfaction was 26.19%,total satisfaction was 88.09%;in the control group after treatment,satisfactory sexual satisfaction was 47.62%,basic satisfaction was 19.05%,total satisfaction was 66.67%,the treatment group was better than control group(P < 0.01).④In therapy group,IIEF-5 from(1.05±0.42)improved to(5.45±1.25);in the control group after treatment,IIEF-5 from(1.04±0.58)improved to(3.24±1.18);the treatment group was better than control group(P < 0.05).⑤42 cases in the control group and 42 patients in the treatment group were no exception.There were 3 cases with bad reactions pleasure during intercourse,1 case with local erythema,after discontinuation,all discomfort disappeared,adverse reaction rate of treatment group was 9.52%,there was no obvious discomfort in therapy group.Conclusion:The effect of Icariin Complex is satisfactory on the primary premature ejaculation and it has higher advantage of convenient-using and high-security.It can improve erectile function of patients.