| 冠心病心血瘀阻证与凝血酶抗凝血酶复合物、血栓调节蛋白的研究 |
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| 引用本文： | 简维雄,黄献平,郑景辉,毛以林,袁肇凯.冠心病心血瘀阻证与凝血酶抗凝血酶复合物、血栓调节蛋白的研究[J].中华中医药学刊,2012(6):1252-1253. |
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| 作者姓名： | 简维雄 黄献平 郑景辉 毛以林 袁肇凯 |
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| 作者单位： | 湖南中医药大学中医诊断研究所国家中医药管理局病理生理学实验室;广西中医学院附属瑞康医院;湖南中医药大学第二附属医院 |
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| 基金项目： | 国家自然科学基金资助项目(30973717);湖南中医药大学青年教师项目(48010101-1) |
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| 摘 要： | 目的:研究凝血酶抗凝血酶复合物、血栓调节蛋白在冠心病心血瘀阻证中的表达。方法:采用ELISA法检测冠心病心血瘀阻证、冠心病非心血瘀阻证、健康者TM、TAT水平。结果:心血瘀阻证组、非心血瘀阻证组TAT水平较健康组高,差异具有显著性(P0.01或P0.05),心血瘀阻证组、非心血瘀阻证组两组间比较差异无显著性(P0.05)。心血瘀阻证组TM水平较高与非心血瘀阻证组健康组比较差异具有显著性(P0.01或P0.05),非心血瘀阻证组与健康组比较差异也具有显著性(P0.01)。结论:冠心病心血瘀阻证存在明显的高凝状态与血管内皮损伤。
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| 关 键 词： | 心血瘀阻证 冠心病 TAT TM |
Research on Coronary blood stasis syndrome and TAT and TM |
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| JIAN Wei-xiong,HUANG Xian-ping,ZHENG Jing-hui,MAO Yi-lin,YUAN Zhao-kai.Research on Coronary blood stasis syndrome and TAT and TM[J].Chinese Archives of Traditional Chinese Medicine,2012(6):1252-1253. |
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| Authors: | JIAN Wei-xiong HUANG Xian-ping ZHENG Jing-hui MAO Yi-lin YUAN Zhao-kai |
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| Institution: | 1 (1.Hunan University of Traditional Chinese Medicine,Changsha 410007,Hunan,China; 2.Ruikang Hospital Affiliated to Guangxi College of Traditional Chinese Medicine,Nanning 530011,Guangxi,China; 3.Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410007,Hunan,China) |
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| Abstract: | Objective:To study the expressions of thrombin-antithrombin complex and thrombomodulin in coronary disease of blood stasis syndrome.Methods:ELISA assay was used to test TM and TAT levels of blood stasis syndrome of coronary heart disease,coronary heart disease of non-blood stasis syndrome and healthy individuals.Results:TAT levels of the blood stasis syndrome group and non-blood stasis syndrome group were higher than that of the healthy group,the difference was significant(P<0.01 or P<0.05),there was no significant difference between blood stasis syndrome group and non-blood stasis syndrome group(P>0.05).Level of TM of blood stasis syndrome group was higher than the non-blood stasis syndrome group as well as health group and the difference was significant(P<0.01 or P<0.05),non-blood stasis syndrome group had significant difference compared with healthy group(P <0.01).Conclusion:It is proved that coronary heart disease of blood stasis syndrome has hypercoagulability and vascular endothelial damage. |
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| Keywords: | blood stasis syndrome coronary heart disease TAT TM |
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