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| 大黄中主要成分清除超氧阴离子自由基的ESR研究 | |
| 引用本文： | 罗志毅,黄新,包国荣.大黄中主要成分清除超氧阴离子自由基的ESR研究[J].中华中医药学刊,2007,25(3):612-614. |
| 作者姓名： | 罗志毅 黄新 包国荣 |
| 作者单位： | 1. 漳州片仔癀药业股份有限公司技术中心,福建,漳州,363000 2. 中国科学院福建物质结构研究所,福建,漳州,350001 3. 福建中医学院药学系,福建,福州,350003 |
| 摘 要： | 目的：通过研究掌叶大黄中主要成分大黄酸、芦荟大黄素、大黄素、大黄素甲醚和大黄酚清除超氧阴离子自由基（O2^-）的作用，从分子生物学的角度探讨大黄延缓衰老作用的可能机理。方法：采用电子自旋共振技术（ESR）分别检测大黄中主要成分对O2^-的清除作用。结果：大黄中主要成分对O2^-的清除作用，依次为大黄酸〉大黄酚〉大黄素〉大黄素甲醚〉芦荟大黄素。结论：大黄所具有的延缓衰老的作用，可能与其所含的主要成分大黄酸、芦荟大黄素、大黄素、大黄素甲醚和大黄酚具有清除O2^-的能力有关。 |
| 关 键 词： | 大黄 药理学 抗氧化剂 自由基清除剂 衰老 药物作用 电子自旋共振(ESR) |
| 文章编号： | 1673-7717（2007）03-0612-03 |
| 收稿时间： | 2006-10-23 |
| 修稿时间： | 2006-10-23 |
ESR Study on the Scavenging Effects of the Main Ingredients in Rheum Palmatum L. on Superoxide Anion Radical |
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| LUO Zhi-yi,HUANG Xin,BAO Guo-rong.ESR Study on the Scavenging Effects of the Main Ingredients in Rheum Palmatum L. on Superoxide Anion Radical[J].Chinese Archives of Traditional Chinese Medicine,2007,25(3):612-614. | |
| Authors: | LUO Zhi-yi HUANG Xin BAO Guo-rong |
| Institution: | 1. Technical Center of Zhangzhou Pientzehuang Pharmaceutical Co. , Ltd. ,Zhangzhou 363000, Fujian, China; 2. Fujian Institue of Research on the Structure of Matter CAS, Fuzhou 350001, Fujian,China; 3. Department of Pharmacy, Fujian College of Traditional Chinese Medicine, Fuzhou 350003, Fujian,China |
| Abstract: | Objective:To study the scavenging effects of Rhein,Aloe-emodin,Emodin,Physcion and Chrysophanol which were the main ingredients in Rheum palmatum L.on superoxide anion radical and to investigate the mechanism of Rheum palmatum L.in retarding aging at molecular biology lever.Methods: The electron spin resonance(ESR)was used to observe the scavenging effect on the superoxide anion radical(O2.-)of the main ingredients in Rheum palmatum L.Results: All of the Rhein,Aloe-emodin,Emodin,Physcion and Chrysophanol were effective in scavenging O2.-produced in the alkaline DMSO system,and the ability was Rhein>Chrysophanol> Emodin>Physcion>Aloe-emodin.Conclusion:Rheum palmatum L.has the effect of retarding aging.Perhaps this is relevant to the scavenging effects on the superoxide anion radical(O2.-)of the main ingredients in the herb. |
| Keywords: | rheum palmatum pharmacol antioxidants free radical scavengers aging drug effect electron spin resonance spectroscopy(ESR) |
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