| 芪参健骨颗粒的制剂工艺研究 |
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| 引用本文： | 尹华,张春霞,王知青,李雯,章建华.芪参健骨颗粒的制剂工艺研究[J].中华中医药学刊,2011(3):465-468. |
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| 作者姓名： | 尹华 张春霞 王知青 李雯 章建华 |
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| 作者单位： | 浙江中医药大学药学院中药标准化研究实验室;浙江中医药大学附属第一医院; |
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| 基金项目： | 浙江省科技厅科技计划项目(2006C33003); 浙江省中药现代化专项资金; 浙江省中医药重点开发项目(2004Z004) |
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| 摘 要： | 目的:优选芪参健骨颗粒的制剂(成型)工艺。方法:以吸湿率、成型率、溶化性、休止角和制粒难易程度为评价指标,单因素试验考察辅料的种类及用量、混合辅料的配比、润湿剂浓度及用量的影响;采用正交试验法进一步优选制剂工艺条件。结果:芪参健骨颗粒最佳制粒工艺条件为:浸膏粉与辅料(糊精∶乳糖=2∶1)按4∶1的比例混合均匀,加1%甜菊素,以90%乙醇为润湿剂,润湿剂用量为辅料与浸膏总量的30%。结论:优选的制剂工艺制备的成品颗粒流动性好,吸湿率、成型率、溶化性、休止角均符合要求,为芪参健骨颗粒制粒工艺条件的确定提供了科学的实验依据。
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| 关 键 词： | 芪参健骨颗粒 正交试验 制剂工艺 |
Pharmaceutical Study of Qishen Jiangu Granules |
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| YIN Hua,ZHANG Chun-xia,WANG Zhi-qing,LI Wen,ZHANG Jian-hua.Pharmaceutical Study of Qishen Jiangu Granules[J].Chinese Archives of Traditional Chinese Medicine,2011(3):465-468. |
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| Authors: | YIN Hua ZHANG Chun-xia WANG Zhi-qing LI Wen ZHANG Jian-hua |
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| Institution: | YIN Hua1,ZHANG Chun-xia1,WANG Zhi-qing1,LI Wen1,ZHANG Jian-hua2(1.Research Laboratory for Standardization of Chinese Medicine,College of Pharmacy,Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China,2.First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006,China) |
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| Abstract: | Objective:To optimize the preparation processes of Qishen jiangu Granules.Methods: Taking hygroscopicity,parallel experimentation,dissolvability,angle of repose,difficulty of granulating as assessing index,use single-factor experiment to research the influence of the type and contents of accessories,the proportion of mixed accessories,the concentration and volume of wetting agent.And the orthogonal experiment was used to further optimize the preparation process condition.Results:It was feasible that the com... |
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| Keywords: | Qishen jiangu Granules orthogonal test Preparation process |
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